Abilify: Side effects, appropriate dosage, utilization for anxiety, and additional details
Abilify is a popular oral tablet medication that's often prescribed for various psychological disorders. Manufactured under the brand name, it contains the active ingredient aripiprazole, classified as an antipsychotic.
The Food and Drug Administration (FDA) has approved Abilify for the following conditions:
- Schizophrenia in adults and adolescents aged 13 years and above
- Manic and mixed episodes related to bipolar I disorder in adults and children aged 10 years and above
- Major depressive disorder (MDD), commonly referred to as depression, in adults
- Irritability associated with autism in children aged 6 years and above
- Tourette syndrome in children aged 6 years and above
Drug specifications
You'll find the fundamental details of Abilify listed below:
- Form: oral tablet
- Availability of a generic alternative?: Yes
- Requires a prescription?: Yes
- Not categorized as a controlled substance?: Yes
- Year of FDA approval: 2002
Other variations of Abilify
Abilify is also available in alternative forms, marketed under different brand names: Abilify MyCite is an oral tablet incorporating a sensor, and Abilify Maintena and Abilify Asimtufii are solutions for injection. Each variant is used to treat distinct conditions. To learn more about Abilify and Abilify Maintena, check out the "Abilify vs. Abilify Maintena" section below. For comprehensive information on Abilify MyCite and Abilify Asimtufii, consult your doctor or pharmacist.
Abilify side effects
Condition Abilify treats in children
Abilify may produce mild or severe side effects. The following list covers some of the common side effects that may arise while taking Abilify. Keep in mind that this is not an exhaustive list.
For comprehensive details about the potential side effects of Abilify, visit this detailed article. Or discuss with your doctor or pharmacist, who can offer advice on managing any bothersome side effects.
Age range
Note: The Food and Drug Administration (FDA) keeps track of adverse drug reactions it has approved. If you have an adverse reaction to Abilify and would like to report it to the FDA, you can do so through MedWatch.
Mild side effects
Use with other drugs
Below is a partial list of mild side effects associated with Abilify. To learn about other mild side effects, consult your doctor or pharmacist, or visit Abilify's prescribing information.
Mild side effects of Abilify can include:
- Nausea, vomiting, or constipation
- Memory loss
- Headache
- Blurry vision or dizziness
- Upper respiratory infection, such as a cold
- Anxiety
- Difficulty falling asleep or staying asleep (insomnia)
- Feelings of restlessness or an urge to move
- Rash
- Hair loss
- Sexual side effects, such as changes in sexual desire or unusual sexual urges
- Mild allergic reactions*
Most of these side effects should subside within a few days or weeks. However, if they worsen or persist, inform your doctor or pharmacist.
schizophrenia
Severe side effects
While serious side effects from Abilify are uncommon, they can occur. Immediately contact your doctor if you experience severe side effects. Reach out to 911 if you believe you're experiencing a medical emergency or if your symptoms appear life-threatening.
ages 13 years and older
Serious side effects and their symptoms can include:
- Manifestations in older individuals afflicted with psychosis (detachment from reality) related to dementia (a disorder characterized by memory decline). Symptoms may include:
- sensations of numbness or weakness on one side of your body
- feelings of disorientation
- difficulty walking
- Neuroleptic malignant syndrome (a serious and uncommon side effect of antipsychotic medications). Symptoms may include:
- elevated body temperature
- rapid heartbeat
- muscle rigidity
- Adjustments in your metabolism, such as diabetes or hypertension of cholesterol. Symptoms can include:
- excessive thirst or hunger
- confusion
- weight gain
- Urges to engage in unusual behaviors or excessively participate in certain activities. Symptoms may include:
- compulsive eating
- gambling
- excessive shopping
- sexual desires
- Orthostatic hypotension (low blood pressure that occurs when shifting from a sitting or lying down position to a standing one), which can result in falls. Symptoms may include:
- dizziness
- fainting
- Decreased count of white blood cells or neutrophils (a specific type of white blood cell). Symptoms may include:
- fever
- persistent infections
- Difficulty with cognitive processes or motor functions. Symptoms may include:
- fatigue
- difficulty concentrating
- reduced motor skills
- Trouble maintaining proper body temperature regulation. Symptoms may include:
- sweating
- redness
- Issue with swallowing. Symptoms may include:
- pain while swallowing
- sensation of food stuck in the throat
- acid reflux
- Extrapyramidal disorder (a motor disorder caused by certain medications). Symptoms may include:
- tremors
- speech problems
- anxiety
- Severe allergic reaction.*
- Motor disorders, such as tremors or tardive dyskinesia (TD).
- Increased risk of mortality in certain elderly individuals.*
- Suicidal thoughts and behaviors in younger individuals.*
may be used on its own or in combination with other drugs if a doctor recommends it
Side effects in children
Frequent side effects noticed in children taking Abilify include:
- feeling drowsy
- tremors (shaking)
- lack of energy
- nausea or vomiting
- fever
- restlessness
- blurred vision
- dizziness
- increased salivation
- changes in appetite
- headache
- nasal congestion
- insomnia (trouble falling or staying asleep)
- weight gain
- muscle stiffness
*ALLERGIC REACTION*As is the case with most medications, some individuals may have an allergic reaction after consuming Abilify. However, the number of individuals with an allergic reaction to Abilify during its clinical trials remains unknown.
manic or mixed episodes related to bipolar I disorder
Mild symptoms of an allergic reaction could include:
- rash
- itching
- flushing
ages 10 years and older
A more severe allergic reaction is uncommon but possible. Symptoms of a severe allergic reaction could include:
- swelling under the skin, usually in the eyelids, lips, hands, or feet
- swelling of the tongue, mouth, or throat
- difficulty breathing
may be used on its own or in combination with either valproate or lithium
If you experience an allergic reaction to Abilify, contact your doctor immediately. In case your symptoms feel life-threatening or if you suspect a medical emergency, contact 911 or your local emergency number.
Abilify generic
Abilify includes the main active ingredient aripiprazole, which is also available as a generic medication. Generic drug is essentially an identical replica of the active drug present in a brand-name medication. It is considered to be as safe and effective as the original medication. Generics usually cost less than brand-name compounds.
Abilify is available in the form of swallowable tablets. On the other hand, aripiprazole can be obtained in various forms such as:
irritability that’s related to autism
- swallowable oral tablets
- dissolvable oral tablets that melt in your mouth
- oral solution
The therapeutic applications of aripiprazole may differ based on the formulation prescribed by the doctor. Discuss with your doctor about the most suitable formulation for your condition.
ages 6 years and older
Abilify dosage
The dosage of Abilify prescribed by your doctor will depend upon several factors. These include:
may be used on its own or in combination with other drugs if a doctor recommends it
- the type and severity of the condition you are using Abilify to manage
- your age
- the type of Abilify you are taking
- other medical conditions you may have
The following information provides commonly used or recommended dosages. Nevertheless, strictly adhere to the dosage prescribed by your doctor. Your doctor will determine the appropriate dosage for your requirements.
Drug forms and strengths
Abilify contains the active ingredient aripiprazole. It is available as swallowable tablets in the following strengths: 2 milligrams (mg), 5 mg, 10 mg, 15 mg, 20 mg, and 30 mg.
Tourette syndrome
In the past, other forms of Abilify were available, but they are no longer in circulation. These forms included:
- dissolvable oral tablets that disintegrate in your mouth
- oral solution that is swallowed
- injectable solution that is injected into a muscle
ages 6 years and older
Abilify is authorized to tackle major depressive disorder (MDD), also known as plain old depression, in grown-ups. For this purpose, Abilify is often used in conjunction with other medications. It's not typically used by itself to treat MDD.
You'll need to take Abilify alongside other depression treatments. The common initial dosage of Abilify for MDD in adults is between 2 mg and 5 mg once a day. This dose is then gradually increased by up to 5 mg each week until your depression symptoms lessen.
may be used on its own or in combination with other drugs if a doctor recommends it
The typical maintenance dosage range for Abilify in adults with MDD is between 2 mg and 15 mg daily. In such cases, the maximum daily dose of Abilify is 15 mg.
Dosage for manic and mixed episodes linked to bipolar I disorder
Abilify is approved for use in adults suffering from manic and mixed episodes associated with bipolar I disorder.
For this condition, the common initial dosage of Abilify in adults is 15 mg once daily. If you're taking Abilify with either valproate or lithium, your doctor may suggest a lower initial dosage of Abilify, ranging from 10 mg to 15 mg once daily. (Valproate and lithium are other medications used to manage bipolar disorder.)
The typical maintenance dosage of Abilify in adults with bipolar I disorder is 15 mg once daily. However, some cases may require up to 30 mg of Abilify daily. This is the maximum daily dose for this condition.
For information on Abilify dosage in children with bipolar I disorder, see the section “Children’s dosage” below.
Dosage for schizophrenia
For adults with schizophrenia, the common initial dosage of Abilify for this condition is typically 10 mg to 15 mg once daily. After 2 weeks of treatment, if symptoms of schizophrenia continue, your doctor may increase your daily dose of Abilify.
Abilify
The typical maintenance dosage range of Abilify for schizophrenia is 10 mg to 30 mg daily. For schizophrenia, the maximum daily dose of Abilify is 30 mg.
For information on Abilify dosage in children with schizophrenia, see the section “Children’s dosage” below.
Abilify Maintena
Dosage for irritability linked to autism
Abilify is approved for use in children aged 6 to 17 years old with irritability related to autism.
For information on Abilify dosages in children with irritability linked to autism, see the section “Children’s dosage” below.
Dosage for Tourette syndrome
Active drug
Abilify is approved for use in children aged 6 to 18 years old with Tourette syndrome.
For information on Abilify dosages in children with Tourette syndrome, see the section “Children’s dosage” below.
aripiprazole
Children’s dosage
Below we describe Abilify dosages for children with certain conditions that the drug is approved to treat.
aripiprazole
Dosage for schizophrenia in children
Abilify is approved for use in children aged 13 to 17 years old with schizophrenia.
The typical starting dosage of Abilify for this use is 2 mg once daily. Then after 2 days of treatment, the child's doctor may increase the daily dose to 5 mg. After an additional 2 days, the doctor may increase the Abilify dose to 10 mg daily.
Doses between 10 mg and 30 mg have been studied in children. Your child's doctor will recommend a dosage of Abilify that's right for your child.
Form
Dosage for bipolar I disorder in children
Abilify is approved for use in children aged 10 to 17 years old with manic or mixed episodes related to bipolar I disorder.
oral tablet
The typical starting dosage of Abilify for this use is 2 mg once daily. Then after 2 days of treatment, the child's doctor may increase the daily dose to 5 mg. After an additional 2 days, their doctor may increase their Abilify dose to 10 mg daily.
If the doctor believes that your child needs a higher dose of Abilify, the dosage may be increased by 5 mg each day, up to a maximum of 30 mg daily. This increase in dosage is continued until your child's symptoms of bipolar I disorder lessen.
intramuscular injection
Keep in mind that if your child is taking lithium or valproate along with Abilify, the recommended dosages of Abilify are the same as those described above. (Lithium and valproate are other medications used to treat bipolar disorder.)
Dosage for irritability related to autism in children
Abilify is approved for use in children aged 6 to 17 years old with irritability related to autism.
The typical starting dosage of Abilify for this use is 2 mg once daily. Then the daily dose can be increased to 5 mg daily after at least 1 week. Following this, the daily dose can be increased to 10 mg to 15 mg daily. It’s recommended to wait at least 1 week before increasing Abilify’s dosage.
Uses
The typical maintenance dosage range of Abilify for this use is 5 mg to 15 mg daily.
Dosage for Tourette syndrome in children
• schizophrenia in adults and children ages 13 years and older• manic and mixed episodes related to bipolar I disorder in adults and children 10 years and older• major depressive disorder (MDD)* in adults, in combination with other drugs• irritability that’s related to autism in children ages 6 years and older• Tourette syndrome in children ages 6 years and older
Abilify is approved for use in children aged 6 to 18 years old with Tourette syndrome.
The starting dosage of Abilify for this use is based on the child's body weight, as follows:
• schizophrenia in adults• bipolar I disorder in adults
- If your child weighs less than 50 kg (approximately 110 lbs), their initial dosage of Abilify will be 2 mg daily. After a span of 2 days, their doctor might increase the dosage to 5 mg daily. If following a week, your child continues to exhibit symptoms of Tourette syndrome, their doctor could boost the dose to 10 mg daily.
- If your child weighs 50 kg (approximately 110 lbs) or more, their initial dosage of Abilify will be 2 mg daily. After a lapse of 2 days, their doctor might increase the dosage to 5 mg daily. Subsequently, after 5 days, their dose will be increased to 10 mg daily. If your child continues to exhibit symptoms of Tourette syndrome, their doctor could potentially raise their dose to a maximum daily dose of 20 mg.
Regarding Abilify consumption
The manufacturer of Abilify has not specified the best time to consume the drug. However, taking the medication at approximately the same time each day helps maintain a consistent level of the drug in your body, enhancing its effectiveness.
- If you miss a dose, take it as soon as you remember. But if it's almost time for your next dose, skip the missed dose. Then take your next dose at the usual time. Never take two doses at once to make up for a missed dose.
- Abilify can be taken with or without food.
- Abilify oral tablets should be swallowed whole. They should not be crushed, split, or chewed.
- Abilify is intended for long-term use. If you and your doctor determine that Abilify is safe and effective for you, you'll likely take it long term.
Overdose
Exceeding the recommended dosage of Abilify can lead to serious side effects. Do not use more Abilify than your doctor recommends.
Overdose symptoms
Symptoms of an Abilify overdose can include:
Abilify
- vomiting
- drowsiness
- tremors or convulsions
- aggression
- heart problems, such as atrial fibrillation (a type of abnormal heart rhythm) and increased heart rate
- changes in certain blood tests, such as those used to check your liver and kidney function
- increased or decreased blood pressure
- loss of consciousness
- breathing that slows down or stops completely
What to do in case of overdose
Rexulti
If you believe you've taken an excessive amount of this drug, contact your doctor. You can also call America's Poison Centers at 800-222-1222 or use its online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.
Abilify applications
The Food and Drug Administration (FDA) approves prescription drugs such as Abilify to treat certain conditions. Abilify may also be prescribed for other conditions off-label. Off-label use is when a drug that's approved to treat one condition is used to treat a different condition.
Abilify for depression
Active drug
Abilify is approved for use in combination with antidepressants in adults with major depressive disorder (MDD). Examples of antidepressants include escitalopram (Lexapro), sertraline (Zoloft), and venlafaxine XR (Effexor XR).
MDD, which is often simply called depression, is a serious disease that affects your mood and actions. People with MDD often feel sad or anxious. This condition may affect your daily life, and you possibly may not be able to eat or sleep like usual.
aripiprazole
Other symptoms of depression include feeling hopeless and not having an interest in activities that you used to enjoy. Some people with depression may have suicidal thoughts or behaviors, which are serious and may be life threatening.
If you have new or worsening symptoms of depression, talk with your doctor right away. Your doctor can recommend treatment options, which may include Abilify.
brexpiprazole
Abilify for manic and mixed episodes related to bipolar I disorder
Abilify is approved to treat manic or mixed episodes related to bipolar I disorder. For this use, Abilify can be given to adults and some children.* For this condition, Abilify is approved for use on its own. It's also approved for use in combination with either valproate or lithium. (Valproate and lithium are other drugs used to treat bipolar disorder.)
Bipolar disorder affects your brain and causes you to have changes in your mood and behavior. With bipolar I disorder, you may have manic episodes. During these episodes, you can feel energetic or extremely irritable. And your thoughts may be racing, making it difficult for you to concentrate.
It's also possible to have mixed episodes with bipolar I disorder. During mixed episodes, you have manic symptoms and depression symptoms at the same time.
Form
Symptoms of depression can include feeling sad or hopeless or lacking interest in activities that you used to enjoy. Some people with depression may have suicidal thoughts or behaviors, which are serious and may be life threatening. With mixed episodes, you can have changes in your mood that can be severe.
Abilify is permitted for treating psychosis in some adult and child patients.* Psychosis is a condition that affects an individual's thought processes and behavior.
oral tablet
A myriad of factors can lead to psychosis. These elements include genetic predisposition and alterations in specific neurotransmitter levels (brain chemicals).
Typically, psychosis starts to impact individuals during their adolescent or early adulthood years. Symptoms of psychosis encompass:
oral tablet
- Positive symptoms. These manifestations are experiences or behaviors that arise in individuals with psychosis but do not take place in individuals without the condition. Examples of positive symptoms are hallucinations, unusual beliefs, and adjustments in physical movements.
- Negative symptoms. These symptoms also impact behavior. They may result in minimal or no emotional expression. Additionally, these symptoms may lead to reduced conversational frequency.
- Symptoms affecting memory and cognitive abilities. These symptoms involve issues with attention, memory recall, and concentration.
Abilify for irritability connected to autism
Abilify is authorized to alleviate irritability linked to autism in certain children. For additional information, see the section “Abilify and children” further below.
Abilify for Tourette's Syndrome
Uses
Abilify is approved for treating Tourette's Syndrome in some children. For more information, consult the section “Abilify and children” below.
Abilify for other disorders
• schizophrenia in adults and children ages 13 years and older• manic and mixed episodes related to bipolar I disorder in adults and children ages 10 years and older• major depressive disorder (MDD)* in adults, in combination with other drugs• irritability that’s related to autism in children ages 6 years and older• Tourette syndrome in children ages 6 years and older
Beyond the applications listed here, Abilify may be prescribed for off-label purposes. Off-label drug use is the administration of a drug that has been approved to treat one condition to an unapproved condition. You might wonder if Abilify is utilized for various other disorders. Below is information on potential uses for Abilify beyond its originally approved indications.
Abilify for anxiety disorders (off-label use)
• schizophrenia in adults and children ages 13 years and older• MDD in adults, in combination with other drugs• agitation related to dementia due to Alzheimer’s disease in adults
Abilify is not approved for anxiety disorders treatment. However, it may be prescribed off-label to manage specific anxiety disorders.
Anxiety refers to a range of conditions, as elaborated upon further below. These conditions include:
- generalized anxiety disorder (GAD)
- obsessive-compulsive disorder (OCD)
- post-traumatic stress disorder (PTSD)
Some research has suggested that Abilify may serve as a treatment option for certain individuals with anxiety. However, in some people, Abilify may actually exacerbate anxiety symptoms. Consequently, Abilify may not be suitable for everyone with anxiety.
The optimal dosage of Abilify for anxiety is not established, as the drug is not currently approved for this condition.
If you experience anxiety, discuss the best treatment options for your condition with your doctor.
Off-label use of Abilify for GAD
With GAD, an individual may feel restless or agitated. They may also struggle with insomnia.
Abilify
One study examined how well Abilify worked in people with GAD that had not responded to other medications. The study indicated that there could be potential benefits from Abilify treatment in individuals with GAD.
Abilify for ADHD (under study)
Latuda
Abilify is not approved to treat attention deficit hyperactivity disorder (ADHD). However, the drug is being studied for this purpose. With ADHD, an individual has trouble concentrating. They may also exhibit hyperactivity, which makes it difficult to stay still. ADHD may affect an individual's ability to focus and learn.
A small 2016 study compared Abilify and risperidone (Risperdal) as treatments to help children with both autism spectrum disorder (ASD) and ADHD symptoms. The study found that children with ASD and ADHD symptoms who took Abilify showed a reduction in their ADHD symptoms.
Another study assessed people diagnosed with both ADHD and a mood disorder referred to as disruptive mood dysregulation disorder (DMDD). DMDD triggers irritability, mood shifts, and temper outbursts. In this study, individuals took Abilify in combination with methylphenidate (Ritalin, Metadate). The study showed that this treatment reduced individuals' ADHD symptoms, such as disruptive behavior and attention difficulties. The treatment also reduced individuals' DMDD symptoms.
If you have any concerns about using Abilify to treat ADHD, speak with your doctor. They can recommend appropriate treatment options for your condition.
Active drug
Abilify and children
Abilify is authorized for use in some children suffering from specific mental health conditions. The table below lists these conditions and appropriate age ranges for their treatment with Abilify.
aripiprazole
| | | || --- | --- | --- || Condition Abilify treats in children | Age range | Use with other drugs || schizophrenia | ages 13 years and older | may be used on its own or in combination with other drugs if a doctor recommends it || manic or mixed episodes related to bipolar I disorder | ages 10 years and older | may be used on its own or in combination with either valproate or lithium || irritability that’s related to autism | ages 6 years and older | may be used on its own or in combination with other drugs if a doctor recommends it || Tourette syndrome | ages 6 years and older | may be used on its own or in combination with other drugs if a doctor recommends it |
Keep in mind that Abilify may increase the risk of suicidal thoughts and behaviors in children and young adults aged 24 and younger. (See the section “Abilify Precautions” below for more information.) Due to this risk, Abilify should be used with caution in people aged 24 and younger.
lurasidone
Abilify has only been investigated in grown-ups, not children, suffering from major depressive disorder (MDD). This condition is often colloquially referred to as depression. Due to this, it's unclear if the medication is secure or effective for children with MDD.
To learn more about the ailments Abilify treats in children, consult with your physician.
Frequently Asked Questions About Abilify
Here are responses to some commonly asked questions about Abilify.
Form
Does Abilify boost energy? How will Abilify affect me?
No, Abilify won't make you feel more energized than usual. Actually, for some individuals, Abilify might even make them feel more drowsy than usual.
oral tablet
Certain medications known as stimulants may make you feel more energized than usual. However, Abilify isn't a stimulant drug. Instead, it's an antipsychotic drug.
If you have any questions regarding how Abilify may affect you, check out the "Abilify side effects" section above. Or speak to your doctor or pharmacist.
oral tablet
Is Abilify a controlled substance?
No, Abilify isn't a controlled substance. (Controlled substances are more likely to induce dependence.) Nevertheless, your body might grow dependent on Abilify.
With dependence, your body needs the drug to function normally. Abilify may cause dependence due to its impact on hormones within your brain. Once your body adjusts to the changes caused by Abilify, you might become dependent on the drug.
Because Abilify may cause dependence, it's possible that you'll experience withdrawal symptoms if you stop using it.
Uses
To learn more about this, see the "Abilify withdrawal and dependence" section below. Also, discuss this medication's effect on you with your doctor.
Can Abilify be used to treat bipolar II disorder?
• schizophrenia in adults and children ages 13 years and older• manic and mixed episodes related to bipolar I disorder in adults and children ages 10 years and older• major depressive disorder (MDD)* in adults, in combination with other drugs• irritability that’s related to autism in children ages 6 years and older• Tourette syndrome in children ages 6 years and older
Yes, Abilify is sometimes prescribed off-label to treat bipolar II disorder. However, keep in mind that Abilify isn't approved by the Food and Drug Administration (FDA) to treat bipolar II disorder. (With off-label use, a drug that's approved by the FDA for certain conditions is prescribed for another condition.)
On the other hand, Abilify is approved to treat manic or mixed episodes related to bipolar I disorder. Bipolar disorder affects your brain and causes changes in your mood and behavior.
• schizophrenia in adults and children ages 13 years and older• depressive episodes related to bipolar I disorder in adults and children ages 10 years and older• depressive episodes related to bipolar I disorder in adults, in combination with either lithium or valproate
With bipolar I disorder, you might have manic episodes. During these episodes, you can feel extremely energetic or extremely irritable. Your thoughts may race, making it difficult for you to concentrate. It's also possible to have mixed episodes with bipolar I disorder. With mixed episodes, you have both manic symptoms and depression symptoms simultaneously. This results in changes in your mood that can be severe.
However, with bipolar II disorder, your primary symptom is major depression. With bipolar II disorder, you will also have hypomania, which is a less severe condition than the mania seen with bipolar I disorder.
It's essential to remember that Abilify is approved to treat manic or mixed episodes of bipolar disorder. Because people with bipolar II disorder typically have depressive symptoms, Abilify might not work as effectively for them.
If you have questions about using Abilify to treat bipolar II disorder, talk to your doctor. They can recommend whether Abilify might be an option to treat your condition.
Abilify withdrawal and dependence
It's possible that your body may become dependent on Abilify. But remember that Abilify isn't a controlled substance. (Controlled substances are more likely than other medications to cause dependence.)
With dependence, your body needs the drug to function normally. Abilify may cause dependence due to its impact on hormones within your brain. Once your body adjusts to the changes caused by Abilify, you might become dependent on the drug.
Because Abilify may cause dependence, it's possible that you'll have withdrawal symptoms if you stop taking it.
Type of medication
However, keep in mind that dependence on Abilify has not been studied in humans. So it's not known for sure if everyone who takes the drug will become dependent on it.
It's crucial to speak with your doctor about Abilify withdrawal and dependence if you have a history of drug misuse. Because this medication may cause dependence and withdrawal symptoms, your doctor may recommend a different medication for you that has a lower risk of these complications.
Examples
Withdrawal symptoms and withdrawal timeline of Abilify
The withdrawal symptoms that may occur in people who suddenly stop taking Abilify aren't known for sure. Additionally, it's not known how soon after stopping Abilify you'll have withdrawal symptoms, or how long they'll last.
Withdrawal symptoms of Abilify may include:
- dizziness
- nausea
- anxiety
- muscle twitches
- insomnia
- headache
- nausea
- increased heart rate
benzodiazepines
If you have questions about withdrawal symptoms from Abilify, speak to your doctor or pharmacist.
How to stop taking Abilify
• lorazepam (Ativan)• diazepam (Valium)• alprazolam (Xanax)• clonazepam (Klonopin)
If you're planning to stop taking Abilify, consult with your doctor first about how to taper off the drug. With tapering, your doctor will gradually decrease your dose of the drug so that your body can adjust to the lower dose over time. Tapering off Abilify can help decrease your risk of withdrawal symptoms.
Keep in mind that the lowest dose that Abilify tablets are made in is 2 mg. So if you're taking 2 mg of Abilify daily and you're planning to stop taking it, your doctor may just have you stop taking your daily dose.
Alternative Medications for Your Condition
If you're seeking options beyond Abilify, various drugs can address your symptoms. Each might suit you better than others. Discuss this with your doctor, and they can suggest other medications that could work well for you.
selective serotonin reuptake inhibitors (SSRIs), a type of antidepressant
- bupropion (Wellbutrin XL)
- venlafaxine XR (Effexor XR)
- brexpiprazole (Rexulti) (same active drug as Abilify, but different form)
- quetiapine (Seroquel)
- lurasidone (Latuda)
- cariprazine (Vraylar)
- paliperidone (Invega)
- sertraline (Zoloft)
- amphetamine/dextroamphetamine (Adderall)
- fluoxetine (Prozac)
Understanding Abilify
• paroxetine (Paxil)• fluoxetine (Prozac)
The exact mechanism of Abilify within your brain isn't fully understood. However, it's speculated that the drug might interact with certain receptors (attachment sites) for brain chemicals. These chemicals include dopamine and serotonin.
Dopamine plays a role in regulating your thoughts and feelings, while serotonin helps in controlling your mood and behavior. Mental health conditions, such as schizophrenia, mania, irritability linked to autism, and Tourette syndrome, might be caused by an imbalance in these brain chemicals. Abilify is approved to treat each of these conditions.
Abilify is believed to help manage these conditions by balancing your dopamine and serotonin levels, ensuring you don't have deficiencies or surpluses of these brain chemicals, resulting in easier control of your thoughts and behaviors.
Abilify or Abilify Maintena: Which is Better for You?
drugs that affect the level of Abilify in your body
You may question the differences between Abilify and Abilify Maintena, which are prescribed for similar purposes. The table below summarizes how these two drugs compare:
| | Abilify | Abilify Maintena || --- | --- | --- || Active drug | aripiprazole | aripiprazole || Form | oral tablet | intramuscular injection || Uses | - Schizophrenia in adults and children (13+)
- Manic & mixed episodes related to bipolar I disorder in adults and children (10+)
- Major depressive disorder (MDD) in adults, in combination with other drugs
- Irritability related to autism in children (6+)
- Tourette syndrome in children (6+)
- Off-label use in ADHD | - Schizophrenia in adults
- Bipolar I disorder in adults |
• itraconazole (Sporanox)• clarithromycin• quinidine• carbamazepine (Tegretol)• rifampin (Rifadin)
Both Abilify and Abilify Maintena share similar side effects due to their shared active ingredient. However, Abilify Maintena may not cause headaches, but it might induce injection site discomfort.
Abilify versus Rexulti
While both drugs may serve similar purposes, Abilify and Rexulti have some differences. The table below summarizes their comparisons:
| | Abilify | Rexulti || --- | --- | --- || Active drug | aripiprazole | brexpiprazole || Form | oral tablet | oral tablet || Uses | - Schizophrenia in adults and children (13+)
- Manic & mixed episodes related to bipolar I disorder in adults and children (10+)
- Major depressive disorder (MDD) in adults, in combination with other drugs
- Irritability related to autism in children (6+)
- Tourette syndrome in children (6+)
- Off-label use in ADHD | - Schizophrenia in adults and children (13+)
- MDD in adults, in combination with other drugs
- Agitation related to dementia due to Alzheimer's disease in adults |
certain blood pressure medications
Both drugs may have similar side effects, but there are also distinct differences. For further information on these medications, consult the prescribing information for Abilify and Rexulti. Your doctor or pharmacist may also provide more details.
Abilify vs. Latuda
• prazosin (Minipress)• doxazosin (Cardura)
Abilify and Latuda share similar indications. The table below outlines their comparisons:
| | Abilify | Latuda || --- | --- | --- || Active drug | aripiprazole | lurasidone || Form | oral tablet | oral tablet || Uses | - Schizophrenia in adults and children (13+)
- Manic & mixed episodes related to bipolar I disorder in adults and children (10+)
- Major depressive disorder (MDD) in adults, in combination with other drugs
- Irritability related to autism in children (6+)
- Tourette syndrome in children (6+)
- Off-label use in ADHD | - Schizophrenia in adults and children (13+)
- Major depressive disorder (MDD) in adults, in combination with other drugs
- Bipolar I disorder in adults and children (13+) |
Both drugs may have similar side effects, but there are certain variations. To learn more about these medications, consult the prescribing information for Abilify and Latuda. Your doctor or pharmacist can also provide more details.
Risperidone (Risperdal) | Lurasidone (Latuda)---------------------------------------|---------------------Main active ingredient | aripiprazole | lurasidone---------------------------------------|---------------------Form | oral tablet | oral tablet---------------------------------------|---------------------Indications | - schizophrenia in adults and children aged 13 years and above*** - manic and mixed episodes associated with bipolar I disorder in adults and children aged 10 years and above*** - major depressive disorder (MDD)** in adults, in combination with other medications - irritability associated with autism in children aged 6 years and above - Tourette syndrome in children aged 6 years and above
certain recreational or illegal drugs
Note: *** denotes the age limit for the use of these medications.
Both Risperidone and Lurasidone have similar and different side effects. To learn more about these medications, including their potential side effects, see this article or the prescribing information for Risperidone and Lurasidone. Your doctor or pharmacist can provide additional information.
• cannabis (commonly called marijuana)• heroin
Risperidone interactions
Risperidone can interact with various other medications. It can also interact with certain foods. It's not known to interact with any herbs or supplements. However, this does not mean that interactions cannot be recognized in the future.
Before starting Risperidone, speak with your doctor and pharmacist. Inform them about all prescription, over-the-counter, and other drugs you take. Also, tell them about any vitamins, herbs, and supplements you use. Sharing this information could help you avoid potential interactions.
Below are some medications, supplements, and foods that can interact with Risperidone. This list does not contain all drugs that may interact with Risperidone.
certain pain relievers
For more information about Risperidone's interactions, see this detailed article. If you have questions about drug interactions that may affect you, consult your doctor or pharmacist.
Medication interactions
• morphine (Mitigo, MS Contin, others)• oxycodone (OxyContin, Roxicodone, others)• fentanyl (Actiq, Fentora, Sublimaze)
The table below lists some types of drugs that may interact with Risperidone.
| | || --- | --- || Type of medication | Examples || benzodiazepines | • lorazepam (Ativan)• diazepam (Valium)• alprazolam (Xanax)• clonazepam (Klonopin) || selective serotonin reuptake inhibitors (SSRIs), a type of antidepressant | • paroxetine (Paxil)• fluoxetine (Prozac) || drugs that affect the level of Risperidone in your body | • itraconazole (Sporanox)• clarithromycin• quinidine• carbamazepine (Tegretol)• rifampin (Rifadin) || certain blood pressure medications | • prazosin (Minipress)• doxazosin (Cardura) || certain recreational or illegal drugs | • cannabis (commonly called marijuana)• heroin || certain pain relievers | • morphine (Mitigo, MS Contin, others)• oxycodone (OxyContin, Roxicodone, others)• fentanyl (Actiq, Fentora, Sublimaze) |
Other interactions: Alcohol and food
If you consume alcohol, it may not be safe to do so while taking Risperidone. If you have questions about the safety of alcohol consumption while taking Risperidone, speak with your doctor or pharmacist.
Risperidone is known to interact with grapefruit. Consuming grapefruit or drinking grapefruit juice while on Risperidone could cause the amount of the drug in your body to build up. Your doctor will advise you to avoid grapefruit products during Risperidone treatment.
If you have any questions about consuming grapefruit or other foods with Risperidone, speak with your doctor.
Risperidone cost
Like all medications, the cost of Risperidone can vary. The actual price you'll pay will depend on your insurance plan, location, and the pharmacy you use.
Drug coupons: You can visit Optum Perks* for price estimates of Risperidone. These estimates are based on the use of Optum Perks coupons. Note: Optum Perks coupons cannot be used with insurance copays or benefits.
To learn more about the price of Risperidone, see this related article.
Financial and insurance assistance: Janssen Pharmaceuticals, Inc., the manufacturer of Risperidone, offers cost savings for this medication. To learn more, visit the manufacturer's website.
To learn more about saving money on prescriptions, refer to this article.
Generic version: Risperidone is available in a generic form called aripiprazole. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. And generics usually cost less than brand-name drugs. To find out how the cost of aripiprazole compares to the cost of Risperidone, speak with your doctor or pharmacist.
This medication carries several warnings and precautions.
FDA Alerts
The Food and Drug Administration (FDA) has issued serious warnings for this drug. A boxed warning is the most severe, alerting doctors and patients about potential risky side effects.
Dangerous risk of death in some elderly individuals. Elderly individuals with psychosis associated with dementia (a condition characterized by memory loss) may face an increased risk of death when using antipsychotic drugs like Abilify. Due to this risk, Abilify should not be prescribed to this specific group of patients.
If you show any signs of dementia-related psychosis while taking Abilify, contact your doctor immediately. They can provide recommendations for suitable treatment options based on your condition.
Increased risk of suicidal thoughts and behaviors in young adults. Abilify might increase the risk of suicidal thoughts and actions in children and adults under 25 years old. Anyone using Abilify may be closely monitored by their doctor for new or worsening depression and suicidal thoughts or actions. If you're on Abilify, your doctor might recommend that your family members keep an eye out for any changes in your mood.
If you start experiencing new or worsened depression, contact your doctor immediately. However, if you're having thoughts of hurting yourself, call 911 or your local emergency service.
Help is available
If you or someone you know is struggling with thoughts of suicide or self-harm, reach out for support:
- Contact the 988 Lifeline at 988 or visit 988lifeline.org. Trained counselors are available 24/7 to listen and provide free and confidential support.
- Text "HOME" to the Crisis Text Line at 741741 to speak with a volunteer crisis counselor 24/7 for free and confidential support.
- Not in the U.S.? Find a helpline in your country via Befrienders Worldwide.
- Call 911 or your local emergency services number if you feel safe doing so.
If you're calling for someone else, stay with them until assistance arrives. You may safely remove any objects or substances that could cause harm if possible.
If you're not in the same household, continue talking with them until help arrives.
Additional cautions
Discuss your medical history with your doctor before using Abilify. This medication might not be suitable for you if you have certain medical conditions or risk factors. Make sure to discuss any of the following with your doctor:
- seizures or convulsions
- suicidal thoughts and behaviors
- diabetes
- high or low blood pressure
- history of stroke or specific heart problems, including heart attack
- low white blood cell level
- issues with an enzyme called CYP2D6 that helps break down medications in the body
- prior allergic reaction to this or a similar drug
Note: For more information about possible side effects of Abilify, see the section "Abilify side effects*" above.
Disclaimer: Medical News Today has made every effort to ensure that all information provided is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the guidance and expertise of a licensed healthcare professional. Always consult your doctor or another healthcare professional before taking any medication. The drug information provided is subject to change and is not intended to cover all possible uses, instructions, warnings, side effects, drug interactions, allergic reactions, or adverse effects. The absence of such information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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- It's important to note that Pfizer, the manufacturer of Abilify, also offers an alternative form of the medication called Abilify MyCite, which contains a sensor and is used to treat distinct conditions.
- In rare cases, individuals may have an allergic reaction to Abilify's active ingredient, aripiprazole, leading to mild symptoms such as rash or hives, or in more severe cases, swelling of the mouth, tongue, or throat.
