Cambridge Researchers Find Rare Gene Variants Boosting Type 2 Diabetes Risk
Researchers at Cambridge University have discovered rare genetic variants that significantly boost the risk of diabetes. The variants, found in the GIGYF1 gene, also link to signs of aging such as reduced muscle strength and increased body fat. The study, published in Nature Communications and funded by the Medical Research Council, sheds new light on the genetic basis of diabetes and aging.
The variants, present in one in 3,000 people, can increase the risk of diabetes from the usual 5% to a staggering 30%. The GIGYF1 gene controls insulin and cell growth factor signaling, making it a promising target for future studies. The research involved DNA sequencing of over 200,000 adults from the UK Biobank study, which is supported by various organizations including Wellcome and the Medical Research Council.
The study's authors, though currently unidentified, have made a significant contribution to understanding the genetic underpinnings of diabetes and its connection to aging. While GIGYF1 has been primarily studied in relation to neurodegenerative diseases like Alzheimer's and Parkinson's, this research highlights its potential role in metabolic disorders.
The discovery of these genetic variants in the GIGYF1 gene offers new avenues for understanding and potentially treating diabetes and its relation to aging. Further research is needed to confirm these findings and explore the therapeutic implications. The UK Biobank and its supporters continue to play a crucial role in advancing medical research.
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