Caplyta's Interactions: Other Drugs, Alcohol, and Related Substances
Caplyta, a medication in the form of capsules, is marketed under the brand name and is utilized for treating schizophrenia and depressive episodes associated with bipolar disorder. This medication may interact with certain other drugs, such as certain antibiotics and antifungal medications.
For more information regarding Caplyta's interactions, continue reading. For additional insights about Caplyta, including its uses, consult this article.
Situations to avoid Caplyta
In certain circumstances, factors or conditions could prevent your physician from prescribing Caplyta due to the potential risk of harm. These are referred to as contraindications. The contraindications of Caplyta include:
Previous allergic reaction to Caplyta or its ingredients
If you've experienced an allergic reaction to Caplyta or any of its components, your doctor is unlikely to prescribe Caplyta. The drug's use could potentially initiate another allergic reaction. You can discuss alternative treatments with them that might be more suitable for you.
Note: Before initiating treatment with Caplyta, inform your doctor if this contraindication applies to you. They can assess whether to prescribe Caplyta.
Caplyta and alcohol
No known interaction between Caplyta and alcohol has been established.
Nonetheless, alcohol may exacerbate specific side effects of Caplyta. Examples include drowsiness and digestive issues, such as nausea and vomiting.
If you consume alcohol, consult your doctor before taking Caplyta. They can provide advice on the safe consumption of alcohol during Caplyta treatment.
certain antifungal drugs
Caplyta's interactions with other medications
Before starting treatment with Caplyta, share with your doctor and pharmacist the list of prescription, over-the-counter, and other medications you take. By disclosing this information with them, you may help prevent potential interactions. (To learn whether Caplyta interacts with supplements, herbs, or vitamins, consult the “Caplyta and other interactions” section below.)
• itraconazole (Sporanox, Tolsura)• fluconazole (Diflucan)• ketoconazole
If you have concerns about drug interactions that may affect you, consult your doctor or pharmacist.
The following table highlights drugs that can interact with Caplyta. Keep in mind that this table does not include all drugs that may interact with Caplyta. Some of these interactions are described in more detail just below in “Interactions explained.”
can increase the risk of side effects from Caplyta*
| Drug class or drug name | Drug examples | Interaction result with Caplyta || --- | --- | --- || certain antifungal drugs | • itraconazole (Sporanox, Tolsura)• fluconazole (Diflucan)• ketoconazole | can increase the risk of side effects from Caplyta* || certain antibiotic drugs | • rifampin (Rifadin, Rimactane)• ciprofloxacin (Cipro)• clarithromycin | can make Caplyta less effective than usual or increase the risk of side effects from Caplyta* || certain HIV drugs | • ritonavir (Norvir)• efavirenz• nelfinavir (Viracept) | can make Caplyta less effective than usual or increase the risk of side effects from Caplyta* || certain seizure drugs | • carbamazepine (Carbatrol, Epitol, others)• phenytoin (Dilantin, Phenytek) | can make Caplyta less effective than usual || certain heart drugs | • diltiazem (Cardizem, Tiazac, others)• verapamil (Verelan, others) | can increase the risk of side effects from Caplyta* || bupropion (Wellbutrin XL, Wellbutrin SR) | — | can increase the risk of side effects from Wellbutrin XL or Wellbutrin SR || lamotrigine (Lamictal) | — | can increase the risk of side effects from Lamictal || quetiapine (Seroquel) | — | can increase the risk of side effects from Seroquel |
* To learn more about Caplyta’s side effects, see this article.
Interactions explained
Certain antifungal drugs
certain antibiotic drugs
Antifungals are medications used to treat fungal infections.
Interaction result: Taking Caplyta in combination with certain antifungal drugs can increase the risk of side effects from Caplyta.
• rifampin (Rifadin, Rimactane)• ciprofloxacin (Cipro)• clarithromycin
Interaction explained: An enzyme called cytochrome P450 3A4 (CYP3A4) breaks down Caplyta in the body. (An enzyme is a type of protein.)
Certain antifungal drugs slow down the activity of CYP3A4. As a result, taking Caplyta with these antifungals could lead to a higher level of Caplyta in your body. A high level of Caplyta in your system could potentially increase your risk of side effects from the drug. (To learn more about Caplyta’s side effects, see this article.)
can make Caplyta less effective than usual or increase the risk of side effects from Caplyta*
Examples of antifungal drugs: Here are some antifungals that may interact with Caplyta:
- itraconazole (Sporanox, Tolsura)
- fluconazole (Diflucan)
- ketoconazole
If your physician assures you it's safe, your healthcare provider might momentarily decrease your Eliquis dosage while you're using an antifungal medication. Lowering the dosage of the drug might help lessen your risk of Eliquis side effects. For further information about Eliquis's dosage, check out this source.
Certain antibiotic drugs
certain HIV drugs
Antibiotic medications are utilized to treat bacterial infections.
Interaction result: The interaction between Eliquis and an antibiotic drug depends on the particular antibiotic.
• ritonavir (Norvir)• efavirenz• nelfinavir (Viracept)
For example, taking Eliquis with rifampin (Rifadin, Rimactane) could reduce Eliquis's effectiveness. On the other hand, taking Eliquis with ciprofloxacin (Cipro) or clarithromycin might increase your risk of side effects from Eliquis.
Interaction explained: An enzyme named CYP3A4 breaks down Eliquis in your body.
can make Caplyta less effective than usual or increase the risk of side effects from Caplyta*
The antibiotic rifampin increases the activity of CYP3A4. Taking Eliquis with rifampin could decrease the amount of Eliquis in your body. This decrease might lower Eliquis's effectiveness.
Ciprofloxacin and clarithromycin, however, slow down the activity of CYP3A4. Taking Eliquis with these antibiotics might raise the amount of Eliquis in your body. Having more Eliquis in your system could raise your risk of side effects with the drug.
Steps you or your doctor may take: If you have a bacterial infection while taking Eliquis, consult your doctor. They can inform you whether you can take the required antibiotic to treat your infection while also using Eliquis.
In some cases, your doctor may temporarily lower your dosage of Eliquis while you take the antibiotic. Decreasing the dosage might help reduce your risk of side effects from Eliquis.
certain seizure drugs
Certain HIV drugs
HIV drugs are used to treat or help prevent HIV.
• carbamazepine (Carbatrol, Epitol, others)• phenytoin (Dilantin, Phenytek)
Interaction result: Using Eliquis with certain HIV drugs could result in various interactions. The particular interaction depends on the specific HIV drug.
For example, using tenofovir with Eliquis could make Eliquis less effective than usual. Alternatively, taking Eliquis with lopinavir (Kaletra) or ritonavir (Norvir) could increase your risk of side effects from Eliquis.
can make Caplyta less effective than usual
Interaction explained: CYP3A4 is an enzyme that breaks down Eliquis in your body.
Tenofovir may increase the activity of CYP3A4. Using Eliquis with this drug might result in a lower amount of Eliquis in your body. This lower amount might make Eliquis less effective for managing your condition.
Lopinavir and ritonavir can decrease the activity of CYP3A4. Using Eliquis with these HIV drugs might raise the amount of Eliquis in your body. Having more Eliquis in your system could raise your risk of side effects from the drug.
Steps you or your doctor may take: Prior to starting Eliquis treatment, inform your doctor if you're using an HIV drug. They can suggest whether it's safe to take these medications together.
certain heart drugs
If your doctor tells you it's safe to take Eliquis with an HIV drug, they may reduce your dosage of Eliquis. Lowering the dosage might help reduce your risk of side effects from Eliquis when these drugs are used together.
Eliquis and other interactions
• diltiazem (Cardizem, Tiazac, others)• verapamil (Verelan, others)
Eliquis may have other interactions, such as with supplements, foods, vaccines, or even lab tests. Below, you'll find details. Remember that the following information does not include all other possible interactions with Eliquis.
Eliquis interactions with supplements
can increase the risk of side effects from Caplyta*
Before starting treatment with Eliquis, inform your doctor and pharmacist about the supplements, herbs, and vitamins you use. Sharing this information with them might help prevent possible interactions.
If you have questions about drug interactions that might affect you, ask your doctor or pharmacist.
Eliquis interactions with herbs
Eliquis might interact with a herbal supplement known as St. John’s wort. Taking Eliquis with this supplement could make Eliquis less effective than usual.
bupropion (Wellbutrin XL, Wellbutrin SR)
As a result, it's important to consult with your doctor or pharmacist before using any herbal supplement while on Eliquis treatment.
Eliquis and vitamins
—
There are no specific reports of vitamins interacting with Eliquis. However, that doesn't imply vitamin interactions won't occur or be recognized in the future. Because of this, you should consult with your doctor or pharmacist before using any vitamin product with Eliquis.
Eliquis interactions with food
can increase the risk of side effects from Wellbutrin XL or Wellbutrin SR
Eating grapefruit or drinking grapefruit juice while using Eliquis could increase your risk of side effects with the drug. (To learn more about Eliquis's side effects, see this article.)
If you'd like to learn more about consuming certain foods during treatment with Eliquis, consult your doctor.
Eliquis and vaccines
There are no specific reports of vaccines interacting with Eliquis. If you have questions about receiving specific vaccines while using Eliquis, consult your doctor or pharmacist.
lamotrigine (Lamictal)
Eliquis and lab tests
There are no specific reports of lab tests interacting with Eliquis. If you have questions about getting specific tests while using Eliquis, consult your doctor or pharmacist.
—
Cannabis AND Caplyta OR CBDCannabis (commonly known as marijuana) and cannabidiol (CBD) derivatives have not been specifically recognized to interfere with Caplyta. However, as with any medication or supplement, it's essential to consult your healthcare provider before using cannabis alongside Caplyta. The impact of cannabis use may influence your adherence to your Caplyta treatment plan.
Note: Cannabis is classified as illegal on a federal level but is legal in various states with varying degrees of legislation.
can increase the risk of side effects from Lamictal
Caplyta AND Interactions with Health-related Factors
Certain medical conditions and other factors might heighten the chance of interactions with Caplyta. Prior to taking this medication, it's crucial to discuss your health history with your doctor. Caplyta may not be the best treatment option for you if you have certain medical conditions or factors impacting your health.
Health conditions or factors that might interact with Caplyta include:
- Individuals aged 65 years or older with dementia-related psychosis: Caplyta may increase the risk of mortality in adults aged 65 years and older with dementia-related psychosis. In fact, Caplyta carries a black box warning regarding this risk. This warning is a serious caution from the Food and Drug Administration (FDA). To learn more, see “Black box warnings” at the beginning of this article.
- Individuals aged 24 years or younger: Caplyta may heighten the risk of suicidal thoughts and behaviors. This risk pertains to both children and adults aged 24 years and younger. Caplyta carries a black box warning about this risk. This warning is a severe caution from the FDA. For more information, see “Black box warnings” at the beginning of this article.
- Liver issues: Before taking Caplyta, make sure to inform your doctor about any liver problems, such as liver failure. They may recommend a reduced Caplyta dosage for you. To learn about Caplyta’s dosing, see this article
- Seizures: Caplyta may cause seizures as a side effect. (For more information about Caplyta’s side effects, see this article.) Prior to taking this drug, inform your doctor if you've experienced seizures. They will advise as to whether Caplyta is safe for you.
- Low white blood cell count: Taking Caplyta can result in lowered white blood cell counts. Having reduced white blood cell levels can increase your risk of infections. If you already have low white blood cell levels, Caplyta may further reduce these levels, increasing your risk of infection. Your doctor can help determine if Caplyta is safe for you.
- Diabetes: Caplyta may cause changes in metabolism that could lead to elevated blood sugar levels. This may exacerbate diabetes in individuals with this condition. Prior to taking Caplyta, inform your doctor if you have diabetes. They may recommend more frequent blood sugar monitoring during Caplyta treatment.
- High cholesterol or triglyceride levels: Caplyta may cause changes in metabolism that could increase the levels of cholesterol or triglycerides in your blood. If you already have high cholesterol or triglycerides, Caplyta could worsen your condition. Your doctor may recommend more frequent cholesterol or triglyceride level monitoring while you're taking Caplyta.
- Heart or blood pressure concerns: If you have a heart or blood pressure problem, inform your doctor before beginning Caplyta treatment. Examples of heart problems include having experienced heart failure or had a heart attack in the past. Caplyta may induce orthostatic hypotension as a side effect. You may have an increased risk of this side effect if you have a heart or blood pressure problem. Speak with your doctor about whether Caplyta is a safe treatment option for you.
- Risk of overheating: Caplyta may affect your body’s ability to regulate temperature. As a result, dehydration, high temperatures, taking certain medications, and vigorous exercise, may cause overheating during Caplyta treatment. This side effect could be harmful. Prior to starting treatment, discuss any risks of overheating with your doctor.
- Pregnancy: It is not known whether Caplyta is safe to use during pregnancy. If you’re pregnant or planning a pregnancy, consult with your doctor before taking this medication. For details about Caplyta's use during pregnancy, see this article.
- Breastfeeding: It’s suggested that you avoid breastfeeding while taking Caplyta. If you’re contemplating breastfeeding while taking Caplyta, speak with your doctor. To learn more about Caplyta’s use while breastfeeding, see this article.
- Allergic reactions: If you’ve had an allergic reaction to Caplyta or any of its ingredients, your doctor will likely not prescribe Caplyta. Using the drug could trigger another allergic reaction. You may ask them about other treatment options that may be more suitable for you.
quetiapine (Seroquel)
Suicide prevention
If you know someone at immediate risk of self-harm, suicide, or harming another:
—
- Ask the difficult question: “Are you considering suicide?”
- Listen to the person without judgment.
- Contact 911 or your local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
- Stay with the person until professional help arrives.
- Attempt to remove any weapons, medications, or other potentially harmful objects if it’s safe to do so.
If you or someone you're acquainted with is grappling with thoughts of self-harm, a crisis hotline can lend a helping hand. The 988 Suicide and Crisis Lifeline is accessible round the clock at 988. In times of crisis, individuals with hearing impairments can utilize their preferred relay service or dial 711 followed by 988.
can increase the risk of side effects from Seroquel
Discover additional sources.
Warding off encounters
There are certain measures you can implement to minimize interactions with Caplyta. Your physician and pharmacist are crucial allies, so don't hesitate to contact them before commencing treatment. Here are some suggestions:
- Inform them if you consume alcohol.
- Disclose any other medications you're taking, as well as any supplements, herbs, and vitamins.
- Create a medication list, which your doctor and pharmacist can assist you in completing.
It's also essential to scrutinize the Caplyta label and other literature that might accompany the drug. The label could have colored tags hinting at an interaction. The accompanying paperwork, often referred to as the medication guide or patient package insert, could contain more details about potential interactions. (If Caplyta doesn't include paperwork, you can inquire with your pharmacist to print a copy.) If you experience difficulty reading or understanding this information, don't hesitate to consult your doctor or pharmacist.
You can also help minimize interactions with Caplyta by adhering to your doctor's prescribed dosage.
Further resources
In addition to learning about interactions, you might want to delve deeper into Caplyta. These resources could be beneficial:
- Caplyta Synopsis: For a general synopsis of Caplyta, refer to this article.
- Side Effects: If you're curious about Caplyta's side effects, see this article. Alternatively, you can examine the Caplyta prescribing information.
- Dosage Details: To learn about Caplyta's dosage, consult this article.
- Insights into Mental Health: To gain more insight into the ailments Caplyta is used to manage, refer to our mental health hub. You can also peruse our lists of articles about schizophrenia and bipolar disorder.
Disclaimer: Medical News Today has taken great care to ensure that all information is factually accurate, exhaustive, and up-to-date. However, this article should not be used as a replacement for a licensed healthcare professional's knowledge and expertise. Always consult your doctor or another healthcare professional before ingesting any medication. The drug information contained herein is subject to change and should not be construed as a comprehensive guide to all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other details for a particular drug does not imply that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
- If you have a history of drug allergies, particularly to Caplyta or its components, inform your doctor as they might consider alternative treatments due to the potential risk of an allergic reaction.
- Abusing drugs, such as those used for recreational purposes or misusing prescription medications, may negatively affect your mental health and interaction with medications like Caplyta. It's important to discuss drug use with your healthcare provider to ensure proper treatment and safety.
- Individuals with mental health issues like bipolar disorder, schizophrenia, or other psychological conditions should discuss their conditions and medication history with their healthcare provider to ensure that Caplyta is a suitable choice for treatment and to minimize potential interaction risks.
