Interactions of Rexulti with other medications, substances such as alcohol, and additional factors
Rexulti, an atypical antipsychotic medication, is commonly used to treat conditions such as schizophrenia and major depressive disorder. While there is a growing body of research on the interactions between Rexulti and various substances, the specific interaction with cannabidiol (CBD) remains less clear.
Cannabidiol, or CBD, is a compound found in cannabis that is known for its anxiolytic and antidepressant effects. However, no well-documented or detailed specific interactions between Rexulti and CBD have been reported in current clinical resources.
Theoretical concerns about the interaction between Rexulti and CBD include potential pharmacodynamic interactions and metabolic interactions. Pharmacodynamic interactions could potentially alter sedation, mood, or cognitive effects, as both substances affect the central nervous system. Metabolic interactions may increase Rexulti levels, increasing the risk of side effects such as sedation or extrapyramidal symptoms, as CBD is known to inhibit the CYP3A4 and CYP2D6 enzymes that metabolize Rexulti.
Despite the limited evidence, it is advisable for patients using both Rexulti and CBD to be closely monitored for increased side effects or altered drug efficacy. It is also recommended to discuss all supplements, including CBD, with your prescribing physician to adjust Rexulti dosage or monitor therapy more closely if combined.
It is important to note that the interaction evidence is more established with other psychiatric drugs like Wellbutrin, where CBD may influence effectiveness or side effects.
In addition to the potential interaction with CBD, Rexulti can interact with a variety of other substances. For instance, drinking alcohol while taking Rexulti may worsen some of its side effects, such as sleepiness, dizziness, impaired judgment, difficulty with thinking or judgment, slowed reactions, headache, and diarrhea.
Rexulti can also interact with certain antibiotics, antifungals, HIV drugs, antidepressants, antiarrhythmics, seizure medications, blood pressure medications, anticholinergic medications, and rifampicin, which can increase the risk of side effects or make Rexulti less effective.
When taking Rexulti, it's crucial to inform your doctor and pharmacist about any other medications, supplements, herbs, or vitamins you are taking. It's also recommended to read the Rexulti label and other accompanying information.
In some cases, certain medical conditions and factors may increase the risk of interactions with Rexulti. Examples include diabetes, high cholesterol or triglycerides, low white blood cell count, low blood pressure, dehydration, risk of falls, heart disease or stroke, seizures, kidney or liver problems, allergic reaction, breastfeeding, pregnancy, and the risk of suicidal thoughts and behaviors.
Taking Rexulti exactly as prescribed by your doctor can help prevent interactions. If you or someone you know is in crisis and considering suicide or self-harm, seek support from the 988 Lifeline, Crisis Text Line, Befrienders Worldwide, or local emergency services.
In conclusion, while specific interactions between Rexulti and CBD are not conclusively reported, caution is advised due to potential metabolic and CNS effects interactions. Proper medical supervision is essential.
- The mental health benefits of cannabidiol (CBD) are well-known, as it has anxiolytic and antidepressant properties.
- However, the specific interaction between Rexulti and CBD is less clear in current clinical resources.
- A pharmacy patient taking Rexulti and CBD should be closely monitored for increased side effects or altered drug efficacy.
- The theoretical concerns about the interaction between Rexulti and CBD include potential pharmacodynamic and metabolic interactions.
- In addition to CBD, Rexulti can interact with various other substances like alcohol, certain antibiotics, antidepressants, and more.
- All supplements, including CBD, should be discussed with your prescribing physician to adjust Rexulti dosage or monitor therapy more closely if combined.
- When taking Rexulti, it's crucial to inform healthcare providers about medical conditions, other medications, and personal factors that may increase the risk of interactions.
