Methotrexate treatment for rheumatoid arthritis: Dosage, safety considerations, and further details
Methotrexate is a disease-modifying antirheumatic drug (DMARD) that is commonly used to treat rheumatoid arthritis (RA). However, it's important to understand the potential risks and proper usage of this medication.
The average oral dosage for methotrexate in RA treatment starts at 7.5-10 milligrams (mg) weekly. For some conditions like psoriasis, the dose may be adjusted up to 25–30 mg per week. Injectable methotrexate, administered either intramuscularly or subcutaneously, has a similar starting dose of 7.5 mg weekly, which can be escalated but typically not above 20 mg per week due to increased toxicity risk.
Long-term or high dosage of methotrexate can increase the risk of liver damage, particularly for those with preexisting liver disease, diabetes, obesity, older adults, or who drink large amounts of alcohol. It's crucial to discuss any pre-existing conditions with your healthcare provider before starting methotrexate treatment.
Methotrexate can cause severe infections due to suppression of the immune system. It's essential to inform your doctor about any upcoming surgeries or vaccinations. Additionally, methotrexate interacts with some common medications, so it's vital to share a list of all prescription and over-the-counter drugs you're currently taking.
If a person forgets to take their dose of methotrexate, they should take it as soon as they remember, but if the dose is more than 2 days late, contact the doctor for advice. Methotrexate should be stored at room temperature, away from excess heat and moisture, and injectable vials should be stored at temperatures of 68-77°F (20-25°C) and away from light.
Side effects of methotrexate may include mouth sores, drowsiness, dizziness, headaches, fatigue, hair loss, nausea, vomiting, and effects on folate levels in the body. These side effects can often be alleviated by taking a daily folate or folic acid supplement, as recommended by a doctor.
It's important to note that methotrexate can take 3-6 weeks to start improving RA symptoms. If a person develops any symptoms such as signs of an infection, unusual bruising or bleeding, pale skin, severe tiredness, shortness of breath, a severe rash or blistering of the skin, confusion or seizures after taking methotrexate, they need medical attention right away.
Lastly, methotrexate is not safe for pregnant or breastfeeding individuals. To use methotrexate for injections, follow specific instructions for preparation, injection site selection, cleaning, and administration. Methotrexate can cause lung damage, liver damage, damage to the lining of the digestive tract, and severe skin reactions.
In conclusion, while methotrexate is an effective treatment for rheumatoid arthritis, it's crucial to understand the potential risks and follow the proper usage guidelines to ensure safe and effective treatment. Always consult with your healthcare provider for personalised advice.
- Methotrexate, a drug commonly used to treat chronic diseases like rheumatoid arthritis, belongs to the category of medical-conditions known as 'disease-modifying antirheumatic drugs (DMARDs)'.
- Apart from RA, methotrexate may also be used to treat other health-and-wellness conditions like psoriasis, but the dosage might vary due to individual factors.
- Science and medicine play a significant role in understanding the therapies-and-treatments available for various medical-conditions, and methotrexate is no exception – its usage and dosage should be discussed carefully with healthcare providers.
- It's essential to note that while Medicare might cover the cost of methotrexate for some individuals, they should be cautious about potential side effects, interactions with other medications, and the increased risk of chronic diseases like anthrax and liver diseases.
