Potential Consequences of Seroquel: Understanding Adverse Reactions and Mitigation Strategies
Seroquel, a popular atypical antipsychotic medication, is used to treat schizophrenia in children aged 13 and above, and mania related to bipolar disorder in children aged 10 and above [1]. Its generic form, quetiapine, is also available as an extended-release oral tablet called Seroquel XR.
Both Seroquel and Seroquel XR share common side effects such as dry mouth, dizziness, headache, sleepiness, and weight gain [1][3]. However, Seroquel XR may cause orthostatic hypotension (a drop in blood pressure upon standing) less frequently [3].
In clinical trials, large increases in blood pressure were reported in children taking Seroquel, which wasn't observed in adults [1]. On the other hand, certain side effects were more commonly reported in clinical trials of Seroquel, such as abdominal pain, weakness, and orthostatic hypotension (a sudden drop in blood pressure when sitting up or standing) [1]. Conversely, clinical trials of Seroquel XR showed nasal congestion, slowed or slurred speech, and increased appetite as more common side effects [1].
Rare but serious side effects, such as prolonged QT interval, cardiac arrhythmias, agranulocytosis, pancreatitis, and suicidal ideation, have been reported with quetiapine (both forms), though these occur at a very low frequency (<1%) [1]. Other less common adverse reactions with quetiapine generally include fever, nightmares, peripheral edema, dyspnea, and palpitations [5].
It is essential to note that no major new types of side effects appear unique to Seroquel XR compared to Seroquel IR according to the summaries from clinical trials. The extended-release version may offer improved tolerability and compliance by reducing peaks and troughs in side effect intensity due to its pharmacokinetic properties [2][3].
When taking Seroquel, side effects such as dry mouth can be worsened by alcohol consumption. Your doctor may suggest limiting or avoiding alcohol during treatment [1]. Additionally, it may be safest to avoid driving until you know how Seroquel may affect you [1].
For more information about the side effects of Seroquel versus Seroquel XR, talk with your doctor or pharmacist [1]. If you experience mild symptoms of an allergic reaction, call your doctor right away. For serious symptoms, immediately call 911 or your local emergency number [1].
References:
[1] Drugs.com. (n.d.). Seroquel XR. Retrieved from https://www.drugs.com/sfx/seroquel-xr-side-effects.html
[2] RxList. (n.d.). Seroquel XR. Retrieved from https://www.rxlist.com/seroquel-xr-side-effects-drug-center.htm
[3] Mayo Clinic. (2021, February 3). Seroquel. Retrieved from https://www.mayoclinic.org/drugs-supplements/seroquel-oral-route/side-effects/drg-20064948
[4] FDA. (n.d.). Seroquel. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021418s039lbl.pdf
[5] Medscape. (n.d.). Quetiapine Fumarate. Retrieved from https://reference.medscape.com/drug/quetiapine-fumarate-seroquel-343480
