Vyvgart Infusion Administration: Details on Dosage, Administration Method, and Timing
Vyvgart (efgartigimod alfa-fcab) and Vyvgart Hytrulo are two medications used to treat generalized Myasthenia Gravis (MG) and chronic inflammatory demyelinating polyneuropathy. While both are effective, they differ in their route of administration, dosage regimen, and administration setting.
Differences Between Vyvgart and Vyvgart Hytrulo
Vyvgart is administered intravenously as an infusion over the course of one hour, while Vyvgart Hytrulo is given as a subcutaneous injection using a prefilled syringe or vial.
The dosage regimen for Vyvgart is weight-based, with a dose of 10 mg per kg of body weight given once weekly for four weeks per treatment cycle. For a person weighing 70 kg, this would equate to a dosage of 700 mg. In contrast, Vyvgart Hytrulo is administered as a fixed dose, with the same amount given each week for four weeks per cycle.
Vyvgart is typically administered by a healthcare professional in a clinic, while Vyvgart Hytrulo can potentially be administered more easily, even at home for subcutaneous injections.
Treatment Cycles and Long-term Use
Treatment cycles for both medications last for four weeks, after which a break is usually observed. Vyvgart is intended for long-term use, and the number of treatment cycles a person receives depends on their response to treatment, including any side effects and effectiveness.
Administration Guidelines
On the day of an infusion, a person may be advised to drink plenty of water, eat as usual, wear comfortable clothing, and bring a list of medications. A healthcare professional will monitor a person during and after the infusion, checking pulse, blood pressure, and temperature.
Important Considerations
Always consult a doctor or healthcare professional before taking any medication. Vyvgart comes as a solution that is administered as an IV infusion, which lasts about one hour. Vyvgart starts to work after the first dose, but its effectiveness is monitored by the doctor throughout treatment.
Vyvgart is a biologic and belongs to a drug class called neonatal Fc receptor blockers. It isn't available in a biosimilar version. If a missed Vyvgart infusion appointment occurs, it should be rescheduled as soon as possible, and the next infusion can be administered if it's within three days of the scheduled dose.
For more information about Vyvgart Hytrulo's dosages, uses, and more, visit the manufacturer's website. The Food and Drug Administration (FDA) has approved Vyvgart to treat generalized myasthenia gravis (MG) in adults who test positive for the anti-acetylcholine receptor antibody.
