Wellbutrin: Details on Adverse Reactions, Prescribed Quantities, Substitutes, and Further Information

Administrator -

What's Up with Wellbutrin?

Wellbutrin: Details on Adverse Reactions, Prescribed Quantities, Substitutes, and Further Information

Wellbutrin is a prescription medicine with two forms, each serving different purposes that have been given the green light by the FDA:

  • Wellbutrin SR. This version of Wellbutrin is meant to tackle major depressive disorder (MDD) in grown-ups. MDD is commonly known as simply depression.
  • Wellbutrin XL. This form of Wellbutrin is used for the same purpose as Wellbutrin SR, that is, dealing with MDD in adults. Additionally, it helps in managing seasonal affective disorder (SAD) in grown-ups.

This text uses "Wellbutrin" interchangeably to refer to both forms of the drug.

The Nitty-Gritty

Wellbutrin contains the active ingredient bupropion. It falls into the category of antidepressants known as norepinephrine and dopamine reuptake inhibitors.

Wellbutrin comes in two forms, each as an oral tablet, with varying strengths. For more information, check out "Wellbutrin SR vs. Wellbutrin XL" below.

Wellbutrin SR vs. Wellbutrin XL

Wellbutrin exists in two variations: Wellbutrin SR and Wellbutrin XL. The "SR" stands for "sustained release," while "XL" signifies "extended release." Both Wellbutrin SR and XL are long-acting and slowly release the active drug into your system over time.

Previously, Wellbutrin was available in an immediate-release (IR) form. (IR refers to the drug's full impact being felt at once.) However, the IR form of Wellbutrin is no longer available.

Wellbutrin SR offers three strengths: 100 milligrams (mg), 150 mg, and 200 mg. Typically, you'll take Wellbutrin SR twice a day.*

Wellbutrin XL is available in two strengths: 150 mg and 300 mg. Normally, you'll take Wellbutrin XL once a day.*

If you're curious about the differences between Wellbutrin SR and Wellbutrin XL, chat with your doctor or pharmacist.

Effectiveness

To learn about Wellbutrin's effectiveness, take a look at the "Wellbutrin uses" section below.

Generic Wellbutrin

Wellbutrin is a brand-name drug with the active ingredient bupropion. This active substance is also available as a generic medication called bupropion ER. A generic drug is an identical replica of the active drug in a brand-name medication.

The generic is just as safe and effective as the original drug. Generics generally cost less than brand-name drugs.

If you're interested in the generic version of Wellbutrin, talk to your doctor. They can inform you if it's available in the right forms and strengths for your condition.

Wellbutrin Side Effects

Wellbutrin may cause mild or serious side effects. Below are some of the main side effects you might experience while taking Wellbutrin.* These lists do not include all potential side effects.

For more information about the possible side effects of Wellbutrin, talk to a doctor or pharmacist, or consult the prescribing information for Wellbutrin SR and Wellbutrin XL.

Note: The Food and Drug Administration (FDA) keeps track of drug side effects it has approved. If you'd like to report a side effect you've experienced with Wellbutrin, you can do so through MedWatch.

Mild side effects

The following is a partial list of mild side effects of Wellbutrin. To learn about other mild side effects, talk to a doctor or pharmacist, or view the prescribing information for Wellbutrin SR and Wellbutrin XL.

Mild side effects of Wellbutrin can include:

  • headache
  • sleep difficulties, such as insomnia or feeling overly tired
  • changes in sexual desire
  • sweating, including night sweats
  • digestive issues, such as loss of appetite, stomach pain, nausea, and constipation
  • hot flashes
  • dry mouth or sore throat
  • dizziness
  • ringing in the ears
  • tremors
  • heart palpitations (a sensation of your heartbeat racing, fluttering, or skipping)
  • muscle pain
  • skin rash
  • weight changes, including weight loss* and weight gain
  • a mild allergic reaction†

Most of these side effects should subside within a few days to a couple of weeks. However, if they worsen or don't go away, talk to a doctor or pharmacist.

Serious side effects

Serious side effects from Wellbutrin are not common, but they can occur. Call a doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you're having a medical emergency.

Serious side effects and their symptoms can include:

  • Vision issues. Symptoms may include:
    • eye discomfort
    • visual alterations
    • redness or inflammation in the eye
  • Seizures. Symptoms may include:
    • tremors, jerks, or spasms
    • changes in taste or smell perception
    • stare into vacuity
    • rapid blinking
    • loss of consciousness
  • High blood pressure, typically won't cause symptoms unless it's severe. Signs of severely high blood pressure may include:
    • headache
    • nosebleeds
    • shortness of breath
    • chest pain
  • Mental health concerns. Examples may include:
    • anxiety*
    • psychosis (loss of connection with reality)
    • delusions (unfounded beliefs or thoughts)
    • hypomania or mania (periods of heightened energy and excitement)
    • panic attacks
    • suicidal thoughts and behaviors
  • Severe allergic reaction.§

*ALLERGIC REACTIONAs with many drugs, some people may have an allergic reaction after taking Wellbutrin. This was a rare occurrence in clinical trials for Wellbutrin SR and Wellbutrin XL*.

Symptoms of a mild allergic reaction may include:

  • skin rash
  • itchiness
  • flushing

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction may include:

  • swelling under the skin, typically in the eyelids, lips, hands, or feet
  • swelling of the tongue, mouth, or throat
  • trouble breathing
  • chest pain

Wellbutrin

Contact a doctor immediately if you experience an allergic reaction to Wellbutrin, as the reaction could worsen. Contact 911 or your local emergency number if your symptoms seem life-threatening or if you believe you're having a medical emergency.

Here are answers to some frequently asked questions about Wellbutrin.

How does Wellbutrin compare with Lexapro and Zoloft?

Below are some ways Wellbutrin compares with Lexapro and Zoloft.

| | | || --- | --- | --- || Wellbutrin | Lexapro | Zoloft || Active drug | bupropion | escitalopram | sertraline || Drug class | norepinephrine and dopamine reuptake inhibitor antidepressant | selective serotonin reuptake inhibitor (SSRI) antidepressant | SSRI antidepressant || Forms | oral pill | oral pill | oral pill and oral solution || Uses | • treatment of major depressive disorder (MDD)• prevention of seasonal affective disorder | treatment of: • MDD• generalized anxiety disorder | treatment of: • MDD• obsessive-compulsive disorder• panic disorder• post-traumatic stress disorder• social anxiety disorder• premenstrual dysphoric disorder |

For more information on how Wellbutrin compares with Lexapro and Zoloft, speak with a doctor or pharmacist.

Is Wellbutrin an SSRI?

No, Wellbutrin is not a selective serotonin reuptake inhibitor (SSRI). Instead, it belongs to a class of drugs called norepinephrine and dopamine reuptake inhibitors (NDRIs).

Lexapro

Both SSRIs and NDRIs are antidepressants. However, they work differently in the body. SSRIs work by boosting levels of a brain substance called serotonin. NDRIs work by raising levels of brain substances called norepinephrine and dopamine. Both of these drug types can aid in improving mood, which can help treat conditions such as depression.

Please speak with a doctor or pharmacist for more information about Wellbutrin and SSRIs.

Could my doctor prescribe Wellbutrin for bipolar disorder, smoking cessation, or other uses?

Possibly. However, Wellbutrin is not approved to treat bipolar disorder or aid in smoking cessation. (Bipolar disorder is a mental health disorder that affects mood and energy level. Smoking cessation refers to the process of quitting smoking.)

Wellbutrin is only approved to treat major depressive disorder and help prevent seasonal affective disorder. (For more details, see the "Wellbutrin uses" section below.)

However, Wellbutrin may be used off-label for other conditions. Off-label drug use is when a drug that's been approved by the Food and Drug Administration (FDA) is prescribed for a purpose other than what it's been approved for. These conditions may include bipolar disorder or smoking cessation.

If you have questions about Wellbutrin and bipolar disorder, smoking cessation, or other uses, speak with your doctor. They can suggest the best treatment option for your condition.

What’s Wellbutrin's half-life?

The half-life of Wellbutrin is about 21 hours. (A drug's half-life is the amount of time it takes for half of a drug's dose to leave your body.) So, it takes about 21 hours for your body to remove half of a dose of Wellbutrin.

Zoloft

It takes around five half-lives for a drug to completely leave your body. For Wellbutrin, this means the drug will remain in your body for about 105 hours, which is around 4 days.

If you have questions about how long Wellbutrin stays in your body, speak with your doctor or pharmacist.

Wellbutrin isn't approved as a weight loss medication, yet weight loss is a common side effect of it. To find out how frequently this side effect appeared in clinical trials, examine the prescription information for both Wellbutrin SR and Wellbutrin XL.

Bupropion (the active component in Wellbutrin) can be used for weight loss. In case your doctor prescribes bupropion for weight loss, they might prescribe it in combination with naltrexone (which is used in Contrave).

If you have any queries about Wellbutrin and weight loss, consult your doctor.

Wellbutrin dosage

The Wellbutrin dosage your doctor prescribes will depend on various factors, such as:

  • whether you utilize Wellbutrin SR or Wellbutrin XL
  • other medical conditions you may have
  • other medications you may be taking

Generally, your doctor will prescribe you a low dose when initiating Wellbutrin therapy. They will then gradually increase it over time to reach the optimal dose for you. Ultimately, your doctor will prescribe the lowest dose of Wellbutrin that produces the desired effect.

The following information describes commonly used or recommended dosages. Nevertheless, take the dosage that your doctor prescribes for you, as they are the best person to determine the best dosage for your needs.

Drug forms and strengths

Wellbutrin is available as an oral tablet in various forms and strengths:

  • Wellbutrin SR: 100 mg, 150 mg, and 200 mg
  • Wellbutrin XL: 150 mg and 300 mg

“SR” signifies sustained release, while “XL” signifies extended-release. Both forms of Wellbutrin are long-acting and release their active drug gradually into your body over time.

Note: In the past, Wellbutrin was also available in an immediate-release (IR) form. (IR means the full dose of the drug is released into your body all at once.) The IR form of Wellbutrin is no longer available. However, the active ingredient in Wellbutrin IR is available in a generic version called bupropion. It comes in strengths of 75 mg and 100 mg.

Dosage for depression

Wellbutrin SR and Wellbutrin XL are used to treat major depressive disorder (MDD), also known as depression.

When used to treat depression, the typical starting dosage of Wellbutrin SR is 150 mg once per day. After 3 days, your doctor may increase your dosage to 150 mg twice per day. The maximum recommended dosage of Wellbutrin SR is 200 mg twice per day.

Active drug

The typical starting dosage of Wellbutrin XL for depression is 150 mg once per day. After 4 days, your doctor may increase your dosage to 300 mg once per day. The maximum recommended dosage of Wellbutrin XL is 450 mg once per day.

Your doctor may prescribe a different dosage of Wellbutrin SR or Wellbutrin XL based on various factors, such as whether you have kidney or liver disease. If you have questions about the dosage that’s right for you, talk with your doctor.

Dosage for ADHD

Wellbutrin SR and Wellbutrin XL are sometimes used off-label to treat Attention Deficit Hyperactivity Disorder (ADHD). (For more information on off-label drug use, see the “Wellbutrin uses” section below.)

When used to treat ADHD, the typical starting dosage of Wellbutrin SR is 150 mg once per day. After 3 days, your doctor may increase your dosage to 150 mg twice per day. The maximum recommended dosage of Wellbutrin SR is 200 mg twice per day.

The typical starting dosage of Wellbutrin XL for ADHD is 150 mg once per day. After 4 days, your doctor may increase your dosage to 300 mg once per day. The maximum recommended dosage of Wellbutrin XL is 450 mg once per day.

Your doctor may prescribe a different dosage of Wellbutrin SR or Wellbutrin XL based on various factors, such as whether you have kidney or liver disease. If you have questions about the dosage that’s right for you, talk with your doctor.

What if I miss a dose?

If you miss a dose of Wellbutrin SR or Wellbutrin XL, wait until your next scheduled dose is due. Do not take any extra doses to make up for a missed dose. Doing so can increase your risk of side effects, particularly seizures. (For information about side effects, see the “Wellbutrin side effects” section above.)

bupropion

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.

Will I need to take this drug long term?

For depression, Wellbutrin SR and Wellbutrin XL are meant to be used as long-term treatments. If you and your doctor determine that Wellbutrin SR and Wellbutrin XL are safe and effective for you, you’ll likely take them long term.

For ADHD, you may take Wellbutrin SR or Wellbutrin XL for short periods or for extended periods based on your doctor's recommendation. Your doctor can provide you with more information on this.

Wellbutrin isn't authorized to tackle Attention Deficit Hyperactivity Disorder (ADHD) by the Food and Drug Administration (FDA). Nevertheless, it can be administered for this condition off-label. Momentarily utilizing a medicine for a purpose other than it's approved for is known as off-label drug use.

ADHD is a condition that may bring about issues controlling conduct or focusing. Symptoms of this condition may incorporate:

  • restlessness or fidgeting
  • talking excessively
  • being effortlessly sidetracked
  • presenting disruptive behaviors, such as angry outbursts

If you have queries regarding taking Wellbutrin for ADHD, converse with your specialist. They can propose the quite treatment for this condition.

Wellbutrin and anxiety

escitalopram

Wellbutrin isn't approved to manage anxiety by the Food and Drug Administration (FDA). Nonetheless, the medication may be utilized off-label for this condition. Off-label drug use is the point at which a medication that’s approved by the Food and Drug Administration (FDA) is recommended for a reason other than what it’s approved for.

Anxiety is a psychological well-being condition that may cause excessive stress or fear about everyday circumstances. Its indications frequently overlap with another condition called obsessive-compulsive disorder (OCD). If bothersome thoughts meddle with day-to-day activities, talk with your specialist. They can assist with deciding whether you may have anxiety, OCD, or another psychological well-being condition.

Remember that Wellbutrin may cause anxiety as a side effect. That is why your specialist may suggest a treatment other than Wellbutrin that doesn’t increase your risk of anxiety.

For example, buspirone is another treatment option for anxiety. In the past, buspirone was accessible under the brand name Buspar. While the generic adaptation of buspirone is still accessible, its brand-name version has been discontinued. If you have anxiety, your specialist can exhort whether buspirone is the right treatment option for you.

If you have different inquiries concerning Wellbutrin and anxiety, talk with your specialist.

Alternatives to Wellbutrin

Different treatment choices are accessible that can be utilized for your condition. Some might be a more reasonable fit for you than others. In case you’re intrigued in discovering an option to Wellbutrin, talk with your specialist. They can reveal to you regarding different choices that may work well for you.

Note: Some of the medications recorded here are utilized off-label to treat these specific conditions. Off-label drug use is the point at which a medication that’s approved by the Food and Drug Administration (FDA) is recommended for a reason other than what it’s approved for.

To learn about Wellbutrin’s off-label uses and alternatives for these conditions, talk with a specialist. For example, Wellbutrin may be recommended off-label for attention deficit hyperactivity disorder (ADHD). (For additional information, see the “Wellbutrin and ADHD” area above.) Your specialist can tell you more regarding alternatives for ADHD, such as amphetamine/dextroamphetamine (Adderall, Adderall XR).

sertraline

Alternatives for depression

Examples of different medications that may be utilized to treat depression include:

  • different antidepressants, such as:
    • escitalopram (Lexapro)
    • sertraline (Zoloft)
    • fluoxetine (Prozac)
    • duloxetine (Cymbalta)
    • paroxetine (Paxil, Pexeva)
    • venlafaxine (Effexor XR)
  • atypical antipsychotics, such as:
    • aripiprazole (Abilify, Abilify Mycite, others)
    • brexpiprazole (Rexulti)
    • quetiapine (Seroquel, Seroquel XR)
    • cariprazine (Vraylar)

Alternatives for seasonal affective disorder

Examples of different medications that may be utilized to treat or help prevent seasonal affective disorder include:

  • different antidepressants, such as:
    • escitalopram (Lexapro)
    • sertraline (Zoloft)
    • fluoxetine (Prozac)
    • duloxetine (Cymbalta)
    • paroxetine (Paxil, Pexeva)
    • venlafaxine (Effexor XR)

Wellbutrin interactions

Wellbutrin can interact with different medications and lab tests. In any case, it’s not known to interact with supplements or foods.

Different interactions can cause different effects. For instance, certain interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more extreme. Drug-condition interactions can also cause specific effects. For information regarding these interactions, see the “Wellbutrin precautions” area below.

Wellbutrin and other medications

Below is a list of medications that can interact with Wellbutrin. This list does not contain all drugs that may interact with Wellbutrin.

Prior to taking Wellbutrin, converse with your specialist and pharmacist. Tell them regarding all prescription, over-the-counter, and different medications you take. Also, tell them regarding any supplements, vitamins, and herbs you use. Sharing this information can help you avoid potential interactions.

  • Monoamine oxidase inhibitors (MAOIs). These substances are employed to address conditions like depression, particular infections, and specific blood disorders. Combining Wellbutrin with MAOIs can lead to dangerously high blood pressure. Examples of such medications include:
    • linezolid (Zyvox)
    • methylene blue (Provayblue)
    • selegiline (Emsam)
    • isocarboxazid (Marplan)
    • phenelzine (Nardil)

Additional drugs that may interfere with Wellbutrin include the following:

  • Certain antiplatelet agents. These drugs are utilized to prevent blood clots in specific scenarios. Co-administering Wellbutrin with antiplatelet agents may enhance the risk of Wellbutrin-related side effects. Examples of these medications include:
    • ticlopidine
    • clopidogrel (Plavix)
  • Certain antiviral agents. These medicines are employed to combat HIV. Co-administering Wellbutrin with antivirals can decrease the effectiveness of Wellbutrin. Examples of these drugs include:
    • efavirenz (Sustiva)
    • lopinavir (Kaletra)
    • ritonavir (Norvir)
  • Certain antiseizure medications. These drugs are used to manage and prevent seizures. Co-administering Wellbutrin with antiseizure medications can decrease the effectiveness of Wellbutrin. Examples of these drugs include:
    • phenobarbital
    • phenytoin (Dilantin, Phenytek)
    • carbamazepine (Epitol, Tegretol, others)
  • Certain antidepressants. These medications are used to address depression. Co-administering Wellbutrin with antidepressants can increase the risk of side effects from antidepressants. Examples of these drugs include:
    • escitalopram (Lexapro)
    • sertraline (Zoloft)
    • fluoxetine (Prozac)
    • duloxetine (Cymbalta)
    • paroxetine (Paxil)
  • Certain antipsychotics. These drugs are used to manage mental health conditions. Co-administering Wellbutrin with antipsychotics can increase the risk of side effects from antipsychotics. Examples of these drugs include:
    • thioridazine
    • risperidone (Risperdal)
    • haloperidol (Haldol)
  • Certain heart rhythm drugs. These medications are used to manage irregular heart rhythms. Co-administering Wellbutrin with heart rhythm drugs can have varying effects, depending on the specific heart rhythm drug. Wellbutrin may either increase the risk of side effects from heart rhythm drugs or make them less effective. Examples of these drugs include:
    • flecainide
    • propafenone
    • digoxin (Lanoxin)
  • Certain beta-blockers. These drugs are used to manage high blood pressure. Co-administering Wellbutrin with beta-blockers can increase the risk of side effects from beta blockers. Examples of these drugs include:
    • metoprolol (Lopressor, Toprol XL)
    • propranolol (Inderal LA, Innopran XL, others)
    • nebivolol (Bystolic)
  • Certain corticosteroids. These medications are used to manage inflammation. Co-administering Wellbutrin with corticosteroids can increase the risk of seizures with Wellbutrin. Examples of these drugs include:
    • methylprednisolone (Medrol)
    • prednisone (Rayos)
    • prednisolone (Orapred ODT, Prelone)
  • Certain dopamine agonists. These medications are used to manage Parkinson’s disease. Co-administering Wellbutrin with these drugs can increase the risk of side effects from both Wellbutrin and dopamine agonists. Examples of these drugs include:
    • amantadine (Gocovri)
    • levodopa-containing drugs
  • The cancer drug tamoxifen (Soltamox). Tamoxifen is employed to treat certain cancers. Co-administering Wellbutrin with this drug can make tamoxifen less effective.
  • The xanthine drug theophylline (Theo-24).Theophylline is employed to manage asthma. Co-administering Wellbutrin with this drug can increase the risk of seizures with Wellbutrin.

If you have queries about drug interactions that may influence you, consult your doctor or pharmacist.

Wellbutrin and herbs and supplements

No herbs or supplements have specifically been reported to interact with Wellbutrin. However, you should still consult with a doctor or pharmacist before utilizing any of these products while on Wellbutrin.

Drug class

Wellbutrin and foods

No foods have specifically been reported to interact with Wellbutrin. If you have any questions about consuming specific foods with Wellbutrin, speak with a doctor.

Wellbutrin and lab tests

Wellbutrin may interact with certain urine drug tests for amphetamines, such as Adderall and Adderall XR.

Specifically, Wellbutrin might lead to a misleading positive test outcome for amphetamines in a urine examination. A misleading positive result occurs when a test indicates a positive presence of a substance despite its absence. In this case, a urine drug test indicates positive amphetamine results, despite Wellbutrin not being an amphetamine.

Before undergoing an amphetamine urine test, ensure your healthcare provider is aware if you are using Wellbutrin. They may opt for an alternate drug test that is unaffected by Wellbutrin.

Wellbutrin and alcohol

You may ponder if alcohol consumption is compatible with Wellbutrin intake. Wellbutrin interacts with alcohol.

The recommendation is to abstain from alcohol consumption while taking Wellbutrin. Reports of mental health alterations have surfaced among individuals consuming alcohol while on Wellbutrin XL and SR. Additionally, these medications might amplify alcohol's effects on your body.

norepinephrine and dopamine reuptake inhibitor antidepressant

If you have concerns about avoiding alcohol while using Wellbutrin, discuss them with your physician.

It is also essential to inform your doctor if you suddenly ceased drinking alcohol during Wellbutrin treatment. Abstaining from alcohol during treatment could increase the risk of seizures as a Wellbutrin side effect. (For more information, refer to the "Wellbutrin precautions" section below.)

Wellbutrin withdrawal and dependence

Wellbutrin is not known to cause drug dependence. (With dependence, your body becomes reliant on a substance to maintain normal functioning.)

Drugs that induce dependence can result in withdrawal symptoms upon cessation of use. (Withdrawal symptoms involve uncomfortable effects experienced after ceasing consumption of a substance.) However, withdrawal symptoms were not observed in clinical trials for Wellbutrin SR and Wellbutrin XL.

Regardless, it is crucial to not cease Wellbutrin treatment abruptly. If you decide to stop taking the drug, consult your physician.

If they recommend it is safe to discontinue, they may reduce your dosage gradually over time. Your doctor might also prescribe an alternate treatment for your underlying condition. Executing these measures could help hinder the resurfacing of your condition's symptoms that Wellbutrin was prescribed to treat.

Wellbutrin uses

The Food and Drug Administration (FDA) authorizes the prescription of certain drugs for specific conditions. Wellbutrin may also be used for unapproved purposes, often termed "off-label." Off-label drug use refers to the prescribing of an FDA-approved drug for a purpose beyond its approved indications.

selective serotonin reuptake inhibitor (SSRI) antidepressant

Wellbutrin for depression

Wellbutrin SR and Wellbutrin XL receive FDA approval to treat major depressive disorder (MDD) in adults. MDD is also known as depression.

Depression explained

With depression, you experience persistent and intense feelings of sadness, impacting daily life.

Symptoms of depression can vary among individuals. Examples include:

  • mood swings
  • sleep disorders, including insomnia or excessive sleepiness
  • changes in weight
  • loss of appetite
  • difficulty concentrating

To learn more about this condition, visit our depression hub.

Effectiveness for depression

Wellbutrin SR and Wellbutrin XL have demonstrated effectiveness in treating depression. These medications are featured as treatment options for depression in guidelines from the American Psychological Association.

SSRI antidepressant

To discover how these drugs performed in clinical trials, consult the prescribing information for Wellbutrin SR and Wellbutrin XL.

Wellbutrin for seasonal affective disorder

Wellbutrin XL is prescribed to help prevent seasonal affective disorder (SAD) in adults. However, Wellbutrin SR is not authorized for this purpose.

Seasonal affective disorder explained

With SAD, you experience symptoms of depression during specific seasons, usually the winter months, improving in the spring.

The symptoms of SAD are identical to those of depression. For a detailed description, please refer to the "Wellbutrin for depression" section above.

To learn more about SAD, visit our depression hub.

Effectiveness for seasonal affective disorder

Wellbutrin XL has shown effectiveness in preventing SAD in clinical trials.

For further information regarding Wellbutrin XL's performance in clinical trials, refer to its prescribing information.

Wellbutrin and children

Wellbutrin is not FDA-approved for use in children. Clinical trials only involved adults. The safety and efficacy of Wellbutrin in children have not been established conclusively.

Wellbutrin use with other drugs

Wellbutrin is prescribed to treat major depressive disorder (MDD) and help prevent seasonal affective disorder (SAD). (To learn more, refer to the "Wellbutrin uses" section above.)

For these indications, your doctor may prescribe Wellbutrin alone or in combination with other medications. Your doctor can suggest whether additional treatment for MDD or SAD prevention is suitable for you.

In some cases, doctors may prescribe medications to assist in managing Wellbutrin's side effects. (To learn more, refer to the "Wellbutrin side effects" section above.)

If you have queries regarding taking Wellbutrin with other drugs, speak with a physician or pharmacist.

Overindulging in Wellbutrin past the suggested dose prescription can result in severe side effects. As a precaution, avoid exceeding the recommended amount prescribed by your medical professional. For a better understanding of the recommended dosage, refer to the "Wellbutrin dosage" section provided above.

Forms

Overdose indications

Symptoms of an overdose might include:

  • Fits or convulsions
  • Loss of consciousness
  • Hallucinations (perceiving or hearing things that aren't present)
  • Irregular heartbeat
  • Exaggerated reflex reactions

In rare situations, an overdose can result in death.

Overdose management

If you suspect you've ingested an excessive amount of this medication, reach out to your doctor. Alternatively, you can contact the American Association of Poison Control Centers at 800-222-1222 or utilize their an online tool.

However, in serious cases, call 911 or your regional emergency number or head straight to the nearest emergency room instantly.

Wellbutrin and pregnancy

The safety of taking Wellbutrin during pregnancy is unclear.

oral tablet

Reports* on the use of Wellbutrin during pregnancy have not shown any risk of congenital abnormalities (commonly known as birth defects). Animal studies have shown issues with fetal development in offspring born to animals that were given the drug during pregnancy. Nevertheless, these animal trials may not necessarily predict human outcomes.

If you're pregnant or planning a pregnancy, consult your physician prior to taking Wellbutrin. They can advise whether it's safe to use Wellbutrin during pregnancy.

The National Pregnancy Registry for Antidepressants is currently collecting data about the effects and safety of Wellbutrin when used during pregnancy. To learn more, visit the registry website or discuss this with your physician.

Wellbutrin and birth control

It's not established whether Wellbutrin is safe to use during pregnancy. If you're sexually active and capable of becoming pregnant, converse with your doctor about your birth control options while you're taking Wellbutrin.

For more information about taking Wellbutrin during pregnancy, refer to the "Wellbutrin and pregnancy" section above.

Wellbutrin and breastfeeding

Wellbutrin has been found to pass through breast milk. However, it's uncertain whether the drug can lead to side effects in a breastfed child.

If you're breastfeeding or considering it, communicate with your doctor before taking Wellbutrin. They can weigh the risks and benefits of breastfeeding during Wellbutrin treatment and suggest alternative feeding methods.

oral tablet

Wellbutrin cost

Similar to other medications, the cost of Wellbutrin can vary. The actual price you'll pay depends on your insurance plan, location, and the pharmacy you use.

Remember that you might be eligible for a 90-day supply of Wellbutrin. If approved by your insurance company, obtaining a 90-day supply could reduce the frequency of trips to the pharmacy and potentially lower the overall cost. Speak with your physician, pharmacist, or insurance company to explore this option.

Before authorizing coverage for Wellbutrin, your insurance company may require you to obtain prior authorization. This means your doctor and insurance company will need to coordinate regarding your prescription prior to the insurance company covering the drug. The insurance company will review the prior authorization request and decide whether the drug will be covered.

If you're uncertain if you'll need to obtain prior authorization for Wellbutrin, contact your insurance company.

Financial and insurance assistance

If you require financial assistance to pay for Wellbutrin or need help understanding your insurance coverage, assistance is offered.

Wellbutrin XL provides a savings and support program. For more information and to determine eligibility, contact 855-330-1963 or visit the program website.

You can search Medicine Assistance Tool and NeedyMeds to discover programs that may help decrease the cost of Wellbutrin SR. To learn more, visit their websites.

oral tablet and oral solution

For more information regarding saving money on prescriptions, consult this article.

Mail-order pharmacies

Wellbutrin might be available through a mail-order pharmacy. Utilizing this service could potentially decrease the drug's cost and enable you to get your medication without leaving home.

If advised by your doctor, you might be able to obtain a 90-day supply of Wellbutrin, thereby alleviating concerns about medication shortage. If interested in this option, inquire with your doctor, pharmacist, or insurance company. Some Medicare plans might also support the cost of mail-order medications.

If you don't have insurance, you can ask your doctor or pharmacist about online pharmacy options.

Generic version

Wellbutrin SR and Wellbutrin XL are available in generic versions referred to as bupropion ER. A generic drug is an exact replica of the active drug found in a brand-name medication. The generic is considered to be as safe and effective as the original drug. And generics typically cost less than brand-name drugs. To learn how the cost of bupropion compares to the cost of Wellbutrin SR or Wellbutrin XL, speak with your physician or pharmacist.

If your physician has prescribed Wellbutrin SR or Wellbutrin XL and you're interested in taking bupropion instead, discuss this with your physician. They may prefer one version over the other. You'll also need to check your insurance plan, as it may only cover one or the other.

This medication carries a grave warning from the Food and Drug Administration (FDA). A boxed warning alerts both physicians and patients about potential drug effects that could pose a danger.

Antidepressants, like Wellbutrin, might boost the likelihood of experiencing depressive thoughts and actions. This risk affects individuals aged 24 years or younger. Nevertheless, Wellbutrin isn't authorized for usage in people below 18 years old.

Depressive thoughts and actions weren't reported during clinical trials for Wellbutrin SR or Wellbutrin XL. However, they surfaced when another form of bupropion was utilized for smoking cessation. (Bupropion is the active ingredient in Wellbutrin.)

It's unclear whether Wellbutrin amplifies the risk of depressive thoughts and actions when used to treat depression or help prevent seasonal affective disorder (SAD). Despite this, during therapy, it's crucial to monitor the following symptoms:

  • sensations of sadness or desperation
  • emotional shifts, such as frustration or agitation (restlessness)
  • thoughts of death
  • anxiety attacks

Keep in mind that depressive thoughts and actions might be indicators of depression. Wellbutrin is employed to treat depression and help prevent SAD, which is a type of depression. It could be challenging to distinguish whether your symptoms are related to Wellbutrin or the condition you're taking the drug to treat or prevent.

If you exhibit symptoms of depressive thoughts or actions while taking Wellbutrin, inform your doctor promptly. They may modify your treatment plan or prescribe a different drug for you. However, if you have thoughts of hurting yourself, dial 911 or your local emergency number.

Assistance is available

If you or someone you know is in crisis and considering suicide or self-harm, seek support:

  • Contact or text the 988 Lifeline at 988 or chat at 988lifeline.org. Empathetic counselors are on hand to listen and provide free and confidential support 24/7.
  • Text HOME to the Crisis Text Line at 741741 to connect with a volunteer crisis counselor for free and confidential support 24/7.
  • Not in the United States? Find a hotline in your country through Befrienders Worldwide.
  • Call 911 or your local emergency services number if you feel secure to do so.

Uses

If you're calling on behalf of someone else, stay with them until help arrives. You can remove weapons or substances that could lead to harm if you can do so safely.

If you're not in the same household, stay on the phone with them until help arrives.

Additional precautions

Before kicking off Wellbutrin therapy, discuss your health background with your doctor. Wellbutrin might not be suitable for you if you have certain medical conditions or other factors affecting your health. These include:

Seizure disorder. Wellbutrin could trigger seizures as a side effect. Before taking the medication, inform your doctor if you have a seizure disorder, such as epilepsy. Your risk of seizures may be higher if you already have a seizure disorder. In this case, your doctor may prescribe a different drug for you.

Current or past eating disorder. If you have bulimia or anorexia or had them in the past, share this information with your doctor before taking Wellbutrin. These conditions might elevate your risk of seizures as a side effect of Wellbutrin. Your doctor can advise whether this medication is safe for you.

Mental health conditions. Before commencing Wellbutrin therapy, inform your doctor if you have any mental health conditions. Examples include bipolar disorder and anxiety. Wellbutrin might induce certain mental health side effects. For instance, the drug may cause hypomania or mania (episodes of high energy and excitement, typically associated with bipolar disorder).

Your risk of these side effects may be higher if you already have bipolar disorder. Moreover, Wellbutrin could worsen anxiety for individuals who already have anxiety before initiating treatment. If you have a mental health condition, your doctor can recommend whether it's safe to take Wellbutrin.

Narrow eye angles. Before beginning Wellbutrin treatment, disclose to your doctor if you have narrow eye angles. Wellbutrin might induce dilated pupils, which could cause closed-angle glaucoma in people with narrow eye angles. Closed-angle glaucoma is a medical emergency that can result in severe eye pain and vision loss. Your doctor may suggest that you undergo an eye exam to check for narrow angles prior to taking Wellbutrin.

• treatment of major depressive disorder (MDD)• prevention of seasonal affective disorder

Stopping treatment with certain drugs or alcohol use. Before taking Wellbutrin, inform your doctor if you've recently discontinued particular medications. These include epilepsy drugs, benzodiazepines, and barbiturates. Additionally, share that you've recently ceased alcohol usage. Stopping usage of these medications or alcohol suddenly might amplify your risk of seizures with Wellbutrin. Your doctor can inform you whether it's safe to take Wellbutrin.

Allergic reaction. If you've experienced an allergic reaction to Wellbutrin or any of its components, your doctor is unlikely to prescribe Wellbutrin to you. Ask your doctor what alternative medications might be more suitable for you.

Pregnancy. It's unclear whether Wellbutrin is safe for use during pregnancy. For further information, see the “Wellbutrin and pregnancy” section above.

Nursing and Wellbutrin. The medication Wellbutrin can be found in breast milk. However, it's unclear whether utilizing Wellbutrin is safe during breastfeeding. Further information can be found in the "Wellbutrin and breastfeeding" section above.

Additional Note: To learn more regarding Wellbutrin's potential negative effects, refer to the "Wellbutrin side effects" section above.

Using Wellbutrin

Your physician will provide you with specific directions for using Wellbutrin.

Wellbutrin is available as tablets that are ingested.

Timing

treatment of: • MDD• generalized anxiety disorder

Take Wellbutrin SR twice a day. Attempt to maintain a consistent schedule for each dose, taking them around the same time each day. You can consume them at any time as long as you wait at least 8 hours between doses.

For Wellbutrin XL, take it once daily, typically in the morning.

Aligning your doses at the same time each day will maintain a consistent level of the drug within your body. This optimizes Wellbutrin's effectiveness.

Consider using a pill reminder to help you remember your doses. This can include setting an alarm or using a timer. You could also use a reminder app on your phone.

Readable Prescriptions and Containers

If your prescription label is difficult to read, consult your physician or pharmacist. Some pharmacies offer labels with large print, braille, or a code that can be scanned with a smartphone to convert text into speech. If your local pharmacy doesn't offer these options, your doctor or pharmacist may be able to direct you to one that does.

If you struggle to open medication bottles, speak with your pharmacist. They may be able to provide Wellbutrin in an easy-to-open container, or recommend tools to simplify opening lids.

Eating with Wellbutrin

Wellbutrin can be taken with or without food. If nausea is a side effect of Wellbutrin, taking your dose with food may help alleviate the nausea (For details regarding Wellbutrin's side effects, see the "Wellbutrin side effects" section above.)

treatment of: • MDD• obsessive-compulsive disorder• panic disorder• post-traumatic stress disorder• social anxiety disorder• premenstrual dysphoric disorder

Crushing, Splitting, or Chewing Wellbutrin Tablets

Do not crush, split, or chew Wellbutrin tablets. Swallow them whole instead.

If you have trouble swallowing the tablets, speak with your physician or pharmacist.

How Wellbutrin Operates

Wellbutrin is authorized for:*

  • treating major depressive disorder (MDD), also known as depression
  • preventing seasonal affective disorder (SAD)

Wellbutrin is classified as an antidepressant. It falls under the drug class of norepinephrine and dopamine reuptake inhibitors. The medication works by boosting brain chemical levels called norepinephrine and dopamine. These chemicals are believed to help regulate mood. By raising levels of these chemicals, Wellbutrin can help treat MDD and prevent SAD.

Time to Effect

Wellbutrin begins working right after your first dose. However, it may take several weeks for your symptoms to improve.

Wellbutrin Expiration, Storage, and Disposal

When you receive Wellbutrin from the pharmacy, the pharmacist will add an expiration date to the bottle's label. This date is usually 1 year after the medication was dispensed.

The expiration date ensures the medication's effectiveness during this period. The FDA recommends discarding expired medications. If you have unused medication that has passed its expiration date, speak with your pharmacist about whether you might still be able to use it.

Storage

Medication lifespan can be influenced by various factors, including how and where it's stored.

Wellbutrin SR tablets should be stored between 68°F and 77°F (20°C and 25°C). Wellbutrin XL should be stored at approximately 77°F (25°C). The drugs can be temporarily stored at temperatures between 59°F and 86°F (15°C to 30°C), such as when traveling.

Store Wellbutrin SR and Wellbutrin XL in tightly sealed containers. Keep Wellbutrin SR away from light. Avoid storing these medications in areas that may be damp or wet, such as bathrooms.

Disposal

If you no longer need to take Wellbutrin and have leftover medication, it's important to dispose of it properly. This helps prevent others, including children and pets, from accidentally ingesting the drug. It also helps protect the environment by keeping the drug out of landfills and water sources.

This article provides helpful tips on medication disposal. You can also ask your pharmacist for advice on disposing of your medication.

Disclaimer: Medical News Today has taken care to present accurate information, but it should not be used as a substitute for professional medical advice. Always consult a licensed healthcare professional before taking any medication. The information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

  1. The anti-depressant Wellbutrin, often used to treat major depressive disorder (MDD) or prevent seasonal affective disorder (SAD), can also help manage symptoms of mental health conditions like depression and anxiety, as it works by increasing levels of norepinephrine and dopamine in the brain.
  2. It's important to discuss with your doctor or pharmacist any potential side effects or interactions when using Wellbutrin, as it's known to cause mild side effects such as headache, insomnia, changes in sexual desire, sweating, and digestive issues, as well as the risk of more serious side effects such as seizures and mental health concerns like anxiety, panic attacks, or suicidal thoughts.
  3. While Wellbutrin can be prescribed for conditions like bipolar disorder or smoking cessation off-label, it's important to consult with a healthcare professional before starting it for any purpose other than its approved uses, as dosage and effectiveness may vary.

Read also: